Results 131 to 140 of about 2,128,083 (311)

Cancer‐Associated Fibroblasts Promote Glucose Metabolic Reprogramming and Progression of Triple‐Negative Breast Cancer via Exosomal circFAD104‐Mediated Intercellular Communication

Advanced Science, EarlyView.
CAF‐derived exosomes deliver circFAD104 into TNBC cells, where it acts as a molecular scaffold that bridges the E3 ligase MARCHF8 and PGM1, promoting MARCHF8‐mediated K48‐linked ubiquitination and proteasomal degradation of PGM1. Loss of PGM1 redirects glucose‐phosphate flux from glycogen synthesis toward glycolysis, thereby driving stemness, EMT, and ...
Lei Wang, Xiaoyan Li, Yiran Liang, Yifei Wang, Yuhan Jin, Jianing Wang, Dan Luo, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Wenjing Zhao, Bing Chen, Lijuan Wang, Qifeng Yang   +16 more
wiley   +1 more source

Epigenetic Reactivation of TNFRSF19 Suppresses Mitophagy and Sensitizes Triple‐Negative Breast Cancer to Doxorubicin

Advanced Science, EarlyView.
TNFRSF19 is an epigenetically silenced regulator of mitophagy in triple‐negative breast cancer. TNFRSF19 deficiency activates the TGFBR1–SMAD3–PINK1 axis to promote mitophagy and confer doxorubicin resistance, whereas decitabine‐mediated restoration of TNFRSF19 suppresses mitophagy and enhances doxorubicin sensitivity, revealing a targetable epigenetic–
Shiyang Liu, Chenguang Liu, Weihong Zheng, Xiaofei Tong, Zhengwei Gui, Zonghong Lu, Sun Ieong, Lin Zhang   +7 more
wiley   +1 more source

Diffuse reflectance and fluorescence spectroscopy for breast conserving surgery

Purpose The major challenge in breast conserving surgery is the high rates of re-excision due to positive resection margins. This study evaluates whether a combined diffuse reflectance spectroscopy (DRS) and laser induced intrinsic fluorescence ...
Chalau, Vadzim, Elson, Daniel S, Shanthakumar, Dhurka, Shi, Yufeng, Ranjitkar, Ria, Leff, Daniel R, Silvanto, Anna, Darzi, Ara   +7 more
core   +1 more source

Targeting LDHA Palmitoylation Sensitizes GBM to Chemoradiotherapy via Suppressing Palmitic Acid Induced Glycolytic Reprogramming

Advanced Science, EarlyView.
Mesenchymal GSCs preferentially uptake palmitic acid, thereby promoting ZDHHC12‐mediated LDHA palmitoylation. This modification enhances LDHA enzymatic activity, drives glycolytic reprogramming, and facilitates exosomal LDHA‐mediated TAM regulation.
Zijie Gao, Rongrong Zhao, Zheyuan Chen, Qingtong Wang, Huanyu Yang, Boyan Li, Yanhua Qi, Shulin Zhao, Jixing Zhao, Jiawei Qiu, Ziwen Pan, Zhe Han, Ruochuan Li, Huize Xia, Weijie Tang, Xing Guo, Ping Zhang, Hongyu Zhao, Xu Qian, Gang Li, Hao Xue   +20 more
wiley   +1 more source

The current diagnosis and treatment strategy of breast cancer based on multicentre retrospective data in Shaanxi province

World Journal of Surgical Oncology
Background Breast cancer is a common malignancy, and early detection coupled with standardized treatment is crucial for patient survival and recovery.
Qin Du, Yize Guo, Yuxuan Zhu, Jingkun Qu, Ya Guo, Shuqun Zhang, Di Liu   +6 more
doaj   +1 more source

Use of breast-conserving surgery for treatment of stage I and stage II breast cancer.

, 1998
PURPOSE To assess the use of breast-conserving surgery in two states reported to differ with respect to surgical treatment of breast cancer. METHODS A retrospective cohort study based on data collected from medical records and patients was performed ...
J H Gurwitz, E Guadagnoli, S B Soumerai, C L Shapiro, C Borbas, J C Weeks   +5 more
core   +1 more source

SOX30 Facilitates Triple‐Negative Breast Cancer Metastasis via TNFR2–NF‐κB Signaling and Tumor Microenvironment Remodeling

Advanced Science, EarlyView.
SOX30 drives triple‐negative breast cancer (TNBC) metastasis through a dual mechanism: direct activation of the TNFR2/NF‐κB signaling cascade and subsequent CCL20‐mediated recruitment of tumor‐associated macrophages (TAMs) into the tumor microenvironment.
Pingping Gao, Na Sun, Ning Yang, Tingting Zhao, Rui Fu, Zhenyu Wu, Yuqin Zhou, Xuanni Tan, Yi Zhang, Fei Han, Xiaowei Qi   +10 more
wiley   +1 more source

Breast Conserving Surgery and Sentinel Lymph Node Biopsy in Locally Advanced Breast Cancer: Single Center Experience

Balkan Medical Journal, 2011
Objective: Patients with locally advanced breast cancer may undergo breast conserving surgery after neoadjuvant chemotherapy. The aim of the study is to evaluate the results of locally advanced breast cancer patients who underwent breast conserving ...
Atakan Sezer, Ruşen Coşar Alas, İrfan Cicin, Zeki Hoşcoşkun, Nermin Tunçbilek   +4 more
doaj  

Volume replacement versus displacement of anterior intercostal artery perforator flap as a reconstructive mode in oncoplastic breast-conserving surgery: A retrospective study

Asian Journal of Surgery
Background: This study aimed to investigate the potential advantages of anterior intercostal artery perforator (AICAP) flap compared to volume displacement (VD) in breast-conserving surgery for cancers located in the lower quadrant of medium to small ...
J.Z. Chen, J.B. Shang, M.Q. Huang, H.Y. Wang, Y. He, Y.P. Wan, Y. Quan, H. Fu, B. Wu, H.Q. Zuo, L.L. Jiang, G.R. Pan   +11 more
doaj   +1 more source

Conservative Surgery for Breast Cancer [PDF]

Journal of the Royal Society of Medicine, 1978
openaire   +2 more sources