Results 31 to 40 of about 612,057 (203)

The measurement of household socio-economic position in tuberculosis prevalence surveys: a sensitivity analysis.

, 2013
OBJECTIVE: To assess the robustness of socio-economic inequalities in tuberculosis (TB) prevalence surveys. DESIGN: Data were drawn from the TB prevalence survey conducted in Lusaka Province, Zambia, in 2005-2006.
Ayles, H, Boccia, D, De Stavola, BL, Fielding, K, Godfrey-Faussett, P, Hargreaves, J, Howe, LD   +6 more
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Texture descriptors applied to digital mammography [PDF]

, 2008
Breast cancer is the second cause of death among women cancers. Computer Aided Detection has been demon- strated an useful tool for early diagnosis, a crucial as- pect for a high survival rate.
Freixenet Bosch, Jordi, Lladó Bardera, Xavier, Mata Miquel, Cristian, Oliver Malagelada, Arnau   +3 more
core  

Plasma levels of leptin and mammographic density among postmenopausal women: a cross-sectional study [PDF]

, 2006
Introduction Obesity has been linked to increased risk of breast cancer in postmenopausal women. Increased peripheral production of estrogens has been regarded as the main cause for this association, but other features of increased body ...
Anne Stuedal, Giske Ursin, Marit B Veierød, Yngve Bremnes, Janne E Reseland, Christian A Drevon, Inger T Gram, PA van den Brandt, TJ Key, PH Lahmann, A Purohit, NF Boyd, RS Ahima, DP Rose, EF van Rossum, V Van Harmelen, A Bado, H Masuzaki, JE Reseland, R Solberg, SM Smith-Kirwin, JM Friedman, RS Ahima, M Otero, A Markowska, P Somasundar, MR Sierra-Honigmann, A Bouloumie, PO Iversen, X Hu, PC Johns, NF Boyd, C Byrne, G Ursin, G Ursin, NF Boyd, IT Gram, Z Ma, G Ursin, W Willett, E Petridou, CS Mantzoros, P Stattin, AS Furberg, PB Lam, TM Salminen, IT Gram, NF Boyd, AV Capuco, LF Silva, G Maskarinec, Z Chen, G Maskarinec, G Maskarinec, NF Boyd, SN O'Brien, K Laud, M Okumura, MP Cleary, MP Cleary, M Ishikawa, F Caldefie-Chezet, A Glasow, S Alowami, X Casabiell, K Kristensen, T Thomas, VD Castracane, C Di Carlo, JA Cauley, DA Magoffin, AJ Fogteloo, J Licinio, A Widjaja, NF Chu, H Fors, NA Lee, C Mantzoros, N Rahimi, AM Lorincz   +79 more
core   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Preventative therapies for healthy women at high risk of breast cancer [PDF]

, 2014
Licensed under the Creative Commons Attribution Non-Commercial ...
Sestak, I
core   +3 more sources

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

The WISDOM Study: breaking the deadlock in the breast cancer screening debate. [PDF]

, 2017
There are few medical issues that have generated as much controversy as screening for breast cancer. In science, controversy often stimulates innovation; however, the intensely divisive debate over mammographic screening has had the opposite effect and ...
Esserman, Laura J, WISDOM Study and Athena Investigators   +1 more
core   +2 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source