Results 41 to 50 of about 320,663 (266)

Are Breast Density and Bone Mineral Density Independent Risk Factors for Breast Cancer? [PDF]

JNCI Journal of the National Cancer Institute, 2005
Mammographic breast density and bone mineral density (BMD) are markers of cumulative exposure to estrogen. Previous studies have suggested that women with high mammographic breast density or high BMD are at increased risk of breast cancer. We determined whether mammographic breast density and BMD of the hip and spine are correlated and independently ...
Karla, Kerlikowske, John, Shepherd, Jennifer, Creasman, Jeffrey A, Tice, Elad, Ziv, Steve R, Cummings   +5 more
openaire   +2 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Opportunistic retrospective assessment of HUAC, bone density, SFT and breast density on CT images and relationship with severity of COVID-19

Journal of Mind and Medical Sciences, 2023
Aim. To evaluate mean Hounsfield unit calculation (HUAC), bone density, subcutaneous fat thickness (SFT), breast density (constitutional imaging biomarkers) and age in symptomatic patients with COVID-19, to assess their correlation with pneumonia ...
Mahmut Subasi, Mustafa Duger, Cengiz Erol, Irmak Durur-Subasi   +3 more
doaj   +1 more source

Generalized breast density metrics

Physics in Medicine & Biology, 2018
Mammograms represent data that can inform future risk of breast cancer. Data from two case-control study populations were analyzed. Population 1 included women (N  =  180 age matched case-control pairs) with mammograms acquired with one indirect x-ray conversion mammography unit.
Erin E E, Fowler, Autumn, Smallwood, Cassandra, Miltich, Jennifer, Drukteinis, Thomas A, Sellers, John, Heine   +5 more
openaire   +2 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Pathological macroscopic evaluation of breast density versus mammographic breast density in breast cancer conserving surgery

European Journal of Obstetrics & Gynecology and Reproductive Biology: X, 2023
Correlation between imaging and anatomopathological breast density has been superficially explored and is heterogeneous in current medical literature. It is possible that mammographic and pathological findings are divergent. The aim of this study is to evaluate the association between breast density classified by mammography and breast density of ...
Yedda Nunes Reis, Bruna Salani Mota, Rosa Maria Salani Mota, Carlos Shimizu, Marcos Desiderio Ricci, Fernando Nalesso Aguiar, José Maria Soares-Jr, Edmund Chada Baracat, José Roberto Filassi   +8 more
openaire   +3 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Fully Automated Breast Density Segmentation and Classification Using Deep Learning

Diagnostics, 2020
Breast density estimation with visual evaluation is still challenging due to low contrast and significant fluctuations in the mammograms’ fatty tissue background.
Nasibeh Saffari, Hatem A. Rashwan, Mohamed Abdel-Nasser, Vivek Kumar Singh, Meritxell Arenas, Eleni Mangina, Blas Herrera, Domenec Puig   +7 more
doaj   +1 more source

Mammographic breast density and breast cancer risk: Evaluation using volumetric breast density software

Journal of Cancer Research and Therapeutics, 2020
The study aimed to assess breast density as a risk factor for breast malignancy using automated volumetric breast density software and to study the relationship of breast density with tumor histopathological characteristics.One hundred and thirty-four women with unilateral core biopsy-proven breast cancer were taken in the "case group." Two hundred and
Suzanne, Koshi, Veenu, Singla, Tulika, Singh, Nidhi, Prabhakar, Amanjit, Bal, Gurpreet, Singh   +5 more
openaire   +2 more sources