Results 61 to 70 of about 320,663 (266)

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Beyond Cancer Detection: An AI Framework for Multidimensional Risk Profiling on Contrast-Enhanced Mammography

Diagnostics
Purpose: The purpose of this study is to assess whether AI-based models improve reproducibility of breast density (BD) and background parenchymal enhancement (BPE) classification and to explore whether contrast-enhanced mammography (CEM) can serve as a ...
Graziella Di Grezia, Antonio Nazzaro, Elisa Cisternino, Alessandro Galiano, Luca Marinelli, Sara Mercogliano, Vincenzo Cuccurullo, Gianluca Gatta   +7 more
doaj   +1 more source

Factors affecting mastectomy specimen density in direct-to-implant breast reconstruction [PDF]

Archives of Aesthetic Plastic Surgery, 2019
Background Direct-to-implant breast reconstruction following nipple-sparing mastectomy is becoming increasingly common. The weight of the breast specimen informs implant selection.
Hyung Suk Yi, Seok Kyung In, Ho Sung Kim, Jin Hyung Park, Hong Il Kim, Chang Wan Jeon, Hyo Young Kim   +6 more
doaj   +1 more source

A Statistical Approach for Breast Density Segmentation [PDF]

Journal of Digital Imaging, 2009
Studies reported in the literature indicate that the increase in the breast density is one of the strongest indicators of developing breast cancer. In this paper, we present an approach to automatically evaluate the density of a breast by segmenting its internal parenchyma in either fatty or dense class.
Arnau Oliver, Xavier Lladó, Elsa Pérez, Josep Pont, Erika R. E. Denton, Jordi Freixenet, Joan Martí   +6 more
openaire   +2 more sources

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Mammographic breast density and cardiovascular disease in women. A literature review

Кардиоваскулярная терапия и профилактика
The world is searching for new simple and economically available gender-specific markers to improve cardiovascular risk stratification in women. The aim of this review was to analyze the association of mammographic density (MD) with cardiovascular ...
E. V. Bochkareva, N. I. Rozhkova, E. K. Butina E. K, I. V. Kim, O. V. Molchanova, S. Yu. Mikushin, P. V. Ipatov, O. M. Drapkina   +7 more
doaj   +1 more source

Comparing measurements of breast density

Physics in Medicine and Biology, 2007
Breast density measurements can be made from mammograms using either area-based methods, such as the six category classification (SCC), or volumetric based methods, such as the standard mammogram form (SMF). Previously, we have shown how both types of methods generate breast density estimates which are generally close.
Highnam, R, Jeffreys, M, McCormack, V, Warren, R, Davey Smith, G, Brady, M   +5 more
openaire   +3 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Breast Imaging Reporting and Data System v2025: Key Updates in Mammography

Journal of the Korean Society of Radiology
In December 2025, the American College of Radiology released the 6th edition of the Breast Imaging Reporting and Data System (BI-RADSⓇ v2025). This review aimed to help radiologists adapt to the updated guidelines by summarizing major changes in ...
Bong Joo Kang
doaj   +1 more source