Results 101 to 110 of about 3,315,884 (301)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Histopathological Spectrum and Treatment Outcomes of Idiopathic Granulomatous Mastitis: A Prospective Cohort Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Idiopathic Granulomatous Mastitis (IGM) is a rare chronic inflammatory breast disease and a diagnosis of exclusion. Although traditionally described as a lobulo-centric disease, ductal involvement has not been systematically assessed.
Aniket Halder, Sumanta Bhattacharya, Rudradeep Banerjee, Saikat Bhattacharya, Soumitra Mondal   +4 more
doaj   +1 more source

Systemic chemokine levels in breast cancer patients and their relationship with circulating menstrual hormones

, 2018
Introduction The chemokines Stromal Cell-Derived Factor-1 alpha (SDF-1 alpha/CXCL12) and Monocyte Chemotactic Protein-1 (MCP-1/CCL2) have been implicated in breast cancer progression. We recently reported elevated systemic MCP-1 in breast cancer patients.
Dwyer, Róisín M., Harrington, Kate A., Potter, Shirley M., Curran, Catherine E., Kerin, Michael J., Hennessy, Emer, Griffin, Damian G.   +6 more
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Nódulo palpable de mama Palpable breast nodule

Revista Colombiana de Obstetricia y Ginecología, 2005
Se realiza una revisión completa del nódulo palpable de mama, con énfasis en su importancia como causa de consulta ginecológica. Se describen las entidades más comunes de la glándula mamaria, tanto benignas como malignas, que se manifiestan como un ...
Gildardo Gallego
doaj  

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Changes in the mammary gland during aging and its links with breast diseases. [PDF]

Acta Biochim Biophys Sin (Shanghai), 2023
Lin J, Ye S, Ke H, Lin L, Wu X, Guo M, Jiao B, Chen C, Zhao L.   +8 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Visit to Breast test Wales, Cardiff

, 1997
Description of a visit to Visit to Breast test Wales, Cardiff by the National Breast Screening ...
National Breast Screening Programme
core  

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source