Results 91 to 100 of about 3,315,884 (301)

Differences in breast cancer hormone receptor status in ethnic groups: a London population.

, 2013
BACKGROUND: Triple negative breast cancer (TNBC) is associated with different ethnic groups in the United States (US), however this has not previously been examined in a population-based study within the United Kingdom (UK). METHODS: Electronic pathology
Jack, Ruth H, Grocock, Melanie J, Renshaw, Christine, Jack, Ruth H., Davies, Elizabeth A.; id_orcid, Coupland, Victoria H, Møller, Henrik, Davies, Elizabeth A., Moller, Henrik; id_orcid, Coupland, Victoria H., Grocock, Melanie J., M�ller, Henrik, Davies, Elizabeth A, Tutt, Andrew   +13 more
core   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Cirugía oncoplástica en cáncer de mama Oncoplastic surgery in mammary cancer

Revista Colombiana de Cirugía, 2008
El cáncer de mama es la enfermedad maligna más frecuente en la mujer; en el año 2002, se presentaron 209.995 casos nuevos con 42.913 muertes en los Estados Unidos y en Colombia, 5.526 casos nuevos con 2.253 muertes.
Nora Beatriz Sánchez, Jaime Rubiano
doaj  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Benign Breast Disease among Patients Visiting the Breast and Endocrine Clinic of a Tertiary Care Centre

Journal of Nepal Medical Association
Introduction: Breast diseases encompass a wide range of conditions, including benign and malignant disorders. Given the significant burden of breast-related health issues in the community, there is a critical need to understand the prevalence.
Sishir Poudel, Sushan Pokharel, Sarada Khadka   +2 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Clinical Application of Artificial Intelligence in Breast Ultrasound

Journal of the Korean Society of Radiology
Breast cancer is the most common cancer in women worldwide, and its early detection is critical for improving survival outcomes. As a diagnostic and screening tool, mammography can be less effective owing to the masking effect of fibroglandular tissue,
John Baek, Jaeil Kim, Hye Jung Kim, Jung Hyun Yoon, Ho Yong Park, Jeeyeon Lee, Byeongju Kang, Iliya Zakiryarov, Askhat Kultaev, Bolat Saktashev, Won Hwa Kim   +10 more
doaj   +1 more source

Mammary masses in Nigerian nuns

International Journal of Medicine and Health Development, 2006
Aim: To study premier parameters of mammary masses in Nigerian nuns. Methods: A prospective study was undertaken by one of us, a nun, as regards the occurrence of breast lumps in fellow members of religious orders living among the Igbos, a populous ...
Mary Angela Muobike, Wilson I B. Onuigbo
doaj  

The role and application potential of cytochrome c in breast cancer therapy

Discover Oncology
Apoptosis plays an important role in all stages of normal breast development, including duct morphogenesis, lactation and proliferative regression. Abnormal apoptosis of breast cells leads to the occurrence of tumors.
Hongshuang Yue, Yumei Fu, Xiuyue Fan, Fulin Zhou, Shu Liu   +4 more
doaj   +1 more source