Results 71 to 80 of about 3,482,222 (258)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Preventative therapies for healthy women at high risk of breast cancer [PDF]

, 2014
Ivana Sestak Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, Charterhouse Square, London, UKAbstract: Tamoxifen has been shown to reduce the risk of developing estrogen receptor (ER)-positive ...
Sestak I, Sestak, I
core   +1 more source

Expression and Role of Epithelial Membrane Proteins in Tumorigenesis of Hormone Receptor-Positive Breast Cancer [PDF]

, 2020
Purpose: Studies on the expression of epithelial membrane proteins (EMPs) in breast cancer have been rare and limited. In the present study, we aimed to evaluate the expression of EMP1, EMP2, and EMP3 in invasive ductal carcinoma (IDC) of the breast, and
구자승, 차윤진
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Visit to Breast test Wales, Cardiff

, 1997
Description of a visit to Visit to Breast test Wales, Cardiff by the National Breast Screening ...
National Breast Screening Programme
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Influence of stromal–epithelial interactions on breast cancer in vitro and in vivo

, 2019
Stromal cell-secreted chemokines including CCL2 have been implicated in the primary tumor microenvironment, as mediators of tumor cell migration, proliferation, and angiogenesis.
Dwyer, Róisín M., Hartmann, Marion C., Khan, Sonja, Potter, Shirley M., Boyle, Marie P., Curran, Catherine E., Kerin, Michael J.   +6 more
core   +1 more source

Psychiatric disorders and cardiovascular diseases during the diagnostic workup of potential breast cancer : a population-based cohort study in Skåne, Sweden [PDF]

, 2019
BACKGROUND: An increasing number of women are evaluated for potential breast cancer and may experience mental distress during evaluation. We aim to assess the risks of psychiatric disorders and cardiovascular diseases during the diagnostic workup of ...
Jöud, Anna, Jöud, Anna,, Fang, Fang,, Fang, Fang, Sparén, Pär,, Schelin, Maria E. C.,, Czene, Kamila,, Cao, Yang,, Sparén, Pär, Fall, Katja, Valdimarsdóttir, Unnur, Cao, Yang, Schelin, Maria E C, Shen, Qing,, Sjölander, Arvid, Valdimarsdóttir, Unnur,, Shen, Qing, Czene, Kamila, Sjölander, Arvid,, Schelin, Maria E. C., Fall, Katja,, Fall, K, Kamila Czene, Yang Cao, Shen, Q,, Arvid Sjölander, Maria E. C. Schelin, Unnur Valdimarsdóttir, Schelin, Maria E C,, Joud, A, Schelin, MEC, Katja Fall, Cao, Y,, Anna Jöud, Valdimarsdottir, U,, Fang, F,, Qing Shen, Sparen, P,, Sjolander, A, Pär Sparén, Czene, K,, Lund University., Fang Fang   +42 more
core   +1 more source

PD-L1 Aptamer–Functionalized Mesoporous Silica Nanoparticles for Targeted Doxorubicin Delivery in Triple-Negative Breast Cancer

International Journal of Nanomedicine
Juntao Tan,1,* Zixi Hu,2,* Da Huang,1,* Lu Chen,1 Liangliang Min,1 Qi-Hua Jiang,3 Zhihua Li1,31Jiangxi Province Key Laboratory of Breast Diseases, Nanchang People’s Hospital/The Affiliated Nanchang People’s Hospital of Nanchang ...
Tan J, Hu Z, Huang D, Chen L, Min L, Jiang QH, Li Z   +6 more
doaj  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source