Results 1 to 10 of about 1,165 (74)

Xanthone-1,2,4-triazine and Acridone-1,2,4-triazine Conjugates: Synthesis and Anticancer Activity

Pharmaceuticals, 2023
A total of 21 novel xanthone and acridone derivatives were synthesized using the reactions of 1,2,4-triazine derivatives with 1-hydroxy-3-methoxy-10-methylacridone, 1,3-dimethoxy-, and 1,3-dihydroxanthone, followed by optional dihydrotiazine ring ...
Sougata Santra, Ainur D. Sharapov, Ramil F. Fatykhov, Anastasya P. Potapova, Igor A. Khalymbadzha, Maria I. Valieva, Dmitry S. Kopchuk, Grigory V. Zyryanov, Alexander S. Bunev, Vsevolod V. Melekhin, Vasiliy S. Gaviko, Andrey A. Zonov   +11 more
doaj   +1 more source

Role of deregulated microRNAs in breast cancer progression using FFPE tissue. [PDF]

PLoS ONE, 2013
MicroRNAs (miRNAs) contribute to cancer initiation and progression by silencing the expression of their target genes, causing either mRNA molecule degradation or translational inhibition.
Liang Chen, Youhuai Li, Yebo Fu, Jin Peng, Meng-Hsuan Mo, Michael Stamatakos, Christine B Teal, Rachel F Brem, Alexander Stojadinovic, Michael Grinkemeyer, Timothy A McCaffrey, Yan-gao Man, Sidney W Fu   +12 more
doaj   +1 more source

High CD90 (THY-1) expression positively correlates with cell transformation and worse prognosis in basal-like breast cancer tumors. [PDF]

PLoS ONE, 2018
Breast cancer is the most prevalent cancer among women, with the basal-like triple negative (TNBC) being the most agressive one, displaying the poorest prognosis within the ductal carcinoma subtype.
Aline Ramos Maia Lobba, Ana Claudia Oliveira Carreira, Otto Luiz Dutra Cerqueira, André Fujita, Carlos DeOcesano-Pereira, Cynthia Aparecida Bueno Osorio, Fernando Augusto Soares, Pranela Rameshwar, Mari Cleide Sogayar   +8 more
doaj   +1 more source

β-Arrestin2 regulates lysophosphatidic acid-induced human breast tumor cell migration and invasion via Rap1 and IQGAP1. [PDF]

PLoS ONE, 2013
β-Arrestins play critical roles in chemotaxis and cytoskeletal reorganization downstream of several receptor types, including G protein-coupled receptors (GPCRs), which are targets for greater than 50% of all pharmaceuticals.
Mistre Alemayehu, Magdalena Dragan, Cynthia Pape, Iram Siddiqui, David B Sacks, Gianni M Di Guglielmo, Andy V Babwah, Moshmi Bhattacharya   +7 more
doaj   +1 more source

Non-redundant roles of the phosphoinositide phosphatases PTEN and PIPP in PI3K/AKT signaling in breast cancer. [PDF]

Commun Biol
Ooms LM, Ferguson DT, Rodgers SJ, Sukhija KK, Jones EI, Csolle MP, Yip HYK, Daly RJ, Tiganis T, McLean CA, Papa A, Mitchell CA.   +11 more
europepmc   +1 more source

Bone sialoprotein: a multifunctional regulator of bone remodelling and tumour progression. [PDF]

Bone Res
Kottmann V, Drees P, Gercek E, Ritz U.
europepmc   +1 more source

HSF2 drives breast cancer progression by acting as a stage-specific switch between proliferation and invasion. [PDF]

Sci Adv
Pessa JC, Paavolainen O, Hästbacka HSE, Puustinen MC, Da Silva AJ, Pihlström S, Gramolelli S, Boström P, Hartiala P, Peuhu E, Joutsen J, Sistonen L.   +11 more
europepmc   +1 more source

CD151 Promotes Cancer Progression in Triple-Negative Breast Cancer by Inducing EMT through the MAPK Signaling Pathway. [PDF]

Breast Cancer (Dove Med Press)
Lv H, Zhang B, Weng X, Li Y, Deng C, Wang R, Shi L, Yin Y.   +7 more
europepmc   +1 more source

Phosphorylation of plectin by Akt3 promotes triple-negative breast cancer cell invasive migration. [PDF]

iScience
Zheng S, Chan C, Asara JM, Zhang L, Wiche G, Chin YR.   +5 more
europepmc   +1 more source

<i>ROPN1</i> Gene Expression as a Prognostic and Predictive Biomarker in Aggressive Breast Cancer: Clinical Implications and Survival Association. [PDF]

Eur J Breast Health
Cintra RC, Céspedes AG, Gamarra OM, Melgarejo CJ, de Bastos DR.   +4 more
europepmc   +1 more source