Results 1 to 10 of about 1,221 (74)

Xanthone-1,2,4-triazine and Acridone-1,2,4-triazine Conjugates: Synthesis and Anticancer Activity

Pharmaceuticals, 2023
A total of 21 novel xanthone and acridone derivatives were synthesized using the reactions of 1,2,4-triazine derivatives with 1-hydroxy-3-methoxy-10-methylacridone, 1,3-dimethoxy-, and 1,3-dihydroxanthone, followed by optional dihydrotiazine ring ...
Sougata Santra, Ainur D. Sharapov, Ramil F. Fatykhov, Anastasya P. Potapova, Igor A. Khalymbadzha, Maria I. Valieva, Dmitry S. Kopchuk, Grigory V. Zyryanov, Alexander S. Bunev, Vsevolod V. Melekhin, Vasiliy S. Gaviko, Andrey A. Zonov   +11 more
doaj   +1 more source

Role of deregulated microRNAs in breast cancer progression using FFPE tissue. [PDF]

PLoS ONE, 2013
MicroRNAs (miRNAs) contribute to cancer initiation and progression by silencing the expression of their target genes, causing either mRNA molecule degradation or translational inhibition.
Liang Chen, Youhuai Li, Yebo Fu, Jin Peng, Meng-Hsuan Mo, Michael Stamatakos, Christine B Teal, Rachel F Brem, Alexander Stojadinovic, Michael Grinkemeyer, Timothy A McCaffrey, Yan-gao Man, Sidney W Fu   +12 more
doaj   +1 more source

High CD90 (THY-1) expression positively correlates with cell transformation and worse prognosis in basal-like breast cancer tumors. [PDF]

PLoS ONE, 2018
Breast cancer is the most prevalent cancer among women, with the basal-like triple negative (TNBC) being the most agressive one, displaying the poorest prognosis within the ductal carcinoma subtype.
Aline Ramos Maia Lobba, Ana Claudia Oliveira Carreira, Otto Luiz Dutra Cerqueira, André Fujita, Carlos DeOcesano-Pereira, Cynthia Aparecida Bueno Osorio, Fernando Augusto Soares, Pranela Rameshwar, Mari Cleide Sogayar   +8 more
doaj   +1 more source

β-Arrestin2 regulates lysophosphatidic acid-induced human breast tumor cell migration and invasion via Rap1 and IQGAP1. [PDF]

PLoS ONE, 2013
β-Arrestins play critical roles in chemotaxis and cytoskeletal reorganization downstream of several receptor types, including G protein-coupled receptors (GPCRs), which are targets for greater than 50% of all pharmaceuticals.
Mistre Alemayehu, Magdalena Dragan, Cynthia Pape, Iram Siddiqui, David B Sacks, Gianni M Di Guglielmo, Andy V Babwah, Moshmi Bhattacharya   +7 more
doaj   +1 more source

SIVA1 Knockdown Drives Aggressive Phenotypes in Triple-Negative Breast Cancer Cells while Enhancing Paclitaxel Efficacy. [PDF]

ACS Omega
Parducci NS, de Almeida BO, Garnique ADMB, Carvalho MFL, Diccini I, Costa-Lotufo LV, Machado-Neto JA.   +6 more
europepmc   +1 more source

Prominin 2 promotes the progression of breast cancer by inhibiting ferroptosis <i>via</i> MAPK signaling. [PDF]

J Transl Int Med
Zhao M, Jin J, Tao Z, Zhao Y, Wang B, Hu X, Wang H.   +6 more
europepmc   +1 more source

ITPP in early pancreatic zebrafish xenografts mildly impacts tumor cell death without interfering with vascular normalization. [PDF]

BMC Cancer
Abou Khouzam R, Amorim F, Rifath A, Thaliffdeen L, Ragupathi P, Nawafleh H, Povoa V, Cruz-Ribeiro M, Lehn JM, Fior R, Limani P, Chouaib S.   +11 more
europepmc   +1 more source

Lactylation of Mutation-Prone RAS Residues Mimics Oncogenic Mutations and Drives Constitutive Activation. [PDF]

Cancer Commun (Lond)
Liao R, Ma C, Chen X, Bai L, Cao Q, Zhang Y, Dong C.   +6 more
europepmc   +1 more source

Discovery and Evaluation of Biomarkers for Triple-Negative Breast Cancer Subtypes Uncovers Patient Stratification and Targeted Therapeutic Strategies. [PDF]

Cancer Res
Ortega-Álvarez D, Tébar-García D, Casado-Peláez M, Olivares-Osuna D, Castillo-Agea E, Balibrea-Rull J, Barbella-Aponte RA, Pérez-Parra D, Musulén E, Guardia C, Vinuesa-Pitarch E, Sánchez-López ME, Postigo-Corrales F, Ballana E, Martínez-Cardús A, Margelí M, Esteller M, Fernández PL, Luengo-Gil G, Mereu E, Galán-Moya EM, Rodilla V.   +21 more
europepmc   +1 more source

Non-redundant roles of the phosphoinositide phosphatases PTEN and PIPP in PI3K/AKT signaling in breast cancer. [PDF]

Commun Biol
Ooms LM, Ferguson DT, Rodgers SJ, Sukhija KK, Jones EI, Csolle MP, Yip HYK, Daly RJ, Tiganis T, McLean CA, Papa A, Mitchell CA.   +11 more
europepmc   +1 more source