Results 31 to 40 of about 2,027 (134)

The effect of chemotherapeutic agents on telomere length maintenance in breast cancer cell lines [PDF]

, 2014
Copyright @ 2014 the authors. This article is made available through the Brunel Open Access Publishing Fund. It is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution ...
Motevalli, A, Roberts, T, Slijepcevic, P, Virmouni, SA, Yasaei, H   +4 more
core   +2 more sources

Inhibition of chemotherapy resistant breast cancer stem cells by a ROR1 specific antibody. [PDF]

, 2019
Breast cancers enduring treatment with chemotherapy may be enriched for cancer stem cells or tumor-initiating cells, which have an enhanced capacity for self-renewal, tumor initiation, and/or metastasis.
Carson, Dennis A, Cui, Bing, Ghia, Emanuela M, He, Jinsong, Huang, Jiajia, Jiang, Wenqi, Kipps, Thomas J, Lam, Sharon, Lei, Yang, Messer, Karen, Parker, Barbara A, Schwab, Richard, Widhopf, George F, Wu, Liufeng, Yu, Jian, Zhang, Han, Zhang, Jianchao, Zhang, Suping   +17 more
core   +1 more source

Functional genomics reveals serine synthesis is essential in PHGDH-amplified breast cancer [PDF]

, 2010
Cancer cells adapt their metabolic processes to drive macromolecular biosynthesis for rapid cell growth and proliferation[superscript 1, 2]. RNA interference (RNAi)-based loss-of-function screening has proven powerful for the identification of new and ...
A Bric, A Marson, Abhishek K. Jha, Albert M. Chan, B Luo, Bingbing Yuan, D Wiederschain, DA Walsh, David E. Root, David M. Sabatini, Dohoon Kim, DR Rhodes, Edward M. Driggers, Elena F. Brachtel, FR Miller, FR Miller, Francesca G. Barrett, Glenn S. Cowley, Hin-Koon Woo, Hyun G. Jang, I Ben-Porath, J Debnath, J Kim, J Moffat, JM Buescher, Jordi Barretina, K Lund, K Snell, Kathleen Ottina, Kevin M. Marks, Kıvanç Birsoy, Levi A. Garraway, Mari Mino-Kenudson, Michael E. Pacold, MJ van de Vijver, Nada Y. Kalaany, Nicolas Stransky, NY Kalaany, Peggy P. Hsu, PP Hsu, R Beroukhim, RG Jones, Richard Possemato, RJ DeBerardinis, S Pollari, Shalini Sethumadhavan, TS Mikkelsen, Walter W. Chen, WE Knox, Y Achouri, Y Sancak, Yoav D. Shaul, Zhi-Yang Tsun   +52 more
core   +1 more source

Advanced Microfluidics for Single Cell‐Based Cancer Research

Advanced Science, Volume 12, Issue 41, November 6, 2025.
Cutting‐edge microfluidic platforms are transforming single‐cell cancer research. This review highlights advanced technologies, from droplet microfluidics to tumour‐chips, that enable functional and spatial single‐cell analyses. By integrating biosensing, immune components, and patient‐derived materials, these systems offer new insights into tumour ...
Adriana Carneiro, Marta Aranda Palomer, Margarida Esteves, Carolina Rodrigues, José Maria Fernandes, Francisca Oliveira, Alexandra Teixeira, Carlos Honrado, Lorena Dieguez, Sara Abalde‐Cela, Miguel Xavier   +10 more
wiley   +1 more source

Integrin-β4 identifies cancer stem cell-enriched populations of partially mesenchymal carcinoma cells [PDF]

, 2017
Neoplastic cells within individual carcinomas often exhibit considerable phenotypic heterogeneity in their epithelial versus mesenchymal-like cell states. Because carcinoma cells with mesenchymal features are often more resistant to therapy and may serve
Bierie, Brian, Chaffer, Christine L., Keckesova, Zuzana, Kroeger, Cornelia, Liu Donaher, Joana, Pattabiraman, Diwakar R., Pierce, Sarah E., Reinhardt, Ferenc, Stover, Daniel G., Thiru, Prathapan, Weinberg, Robert A   +10 more
core   +1 more source

Olive Oil Polyphenols: A Promising Approach for Cancer Prevention and Therapy

Food Science &Nutrition, Volume 13, Issue 9, September 2025.
The manuscript explores the anticancer potential of olive oil polyphenols, specifically hydroxytyrosol and oleuropein, which exhibit potent antioxidant, anti‐inflammatory, and anticancer properties. These bioactive compounds modulate key molecular pathways involved in the initiation and metastasis of cancer. They induce apoptosis, inhibit angiogenesis,
Muhammad Junaid Anwar, Muhammad Hammad Anwar, Muhammad Imran, Ahmad Mujtaba Noman, Muzzamal Hussain, Hassan Raza, Hagar M. Mohamed, Gamal A. Mohamed, Sabrin R. M. Ibrahim, Tadesse Fenta Yehuala, Suliman A. Alsagaby, Waleed Al Abdulmonem, Mohamed A. Abdelgawad, Ehab M. Mostafa, Mohammed M. Ghoneim, Samy Selim   +15 more
wiley   +1 more source

ABCG2, a novel antigen to sort luminal progenitors of BRCA1- breast cancer cells. [PDF]

, 2014
International audienceINTRODUCTION: Tumor-initiating cells (TICs), aka "cancer stem cells", are believed to fuel tumors and to sustain therapy resistance and systemic metastasis.
Ansieau, Stéphane, del Vecchio, Luigi, Di Noto, Rosa, Leccia, Felicia, Mariotti, Elisabetta, Morel, Anne-Pierre, Puisieux, Alain, Salvatore, Francesco   +7 more
core   +4 more sources

Role of the Extracellular Matrix in Cancer: Insights into Tumor Progression and Therapy

Advanced Therapeutics, Volume 8, Issue 2, February 2025.
The extracellular matrix (ECM) is pivotal in cancer progression, influencing tumor growth, metastasis, and therapy resistance. This paper explores ECM remodeling, highlighting components like collagens and proteoglycans, their impact on immune evasion, and emerging therapies targeting ECM mechanics and composition.
Nimeet Desai, Deepak Sahel, Bhakti Kubal, Humzah Postwala, Yesha Shah, Vivek P Chavda, Clara Fernandes, Dharmendra K. Khatri, Lalitkumar K. Vora   +8 more
wiley   +1 more source

Enhanced expression of galectin‐9 in triple negative breast cancer cells following radiotherapy: Implications for targeted therapy

International Journal of Cancer, Volume 156, Issue 1, Page 229-242, 1 January 2025.
What's new? Immune checkpoint inhibitors have radically advanced cancer treatment. Frequently, immune checkpoint inhibitors are combined with radiation, but radiation therapy may spur the development of treatment resistance. Here, the authors show that in triple‐negative breast cancer (TNBC), expression of the immune checkpoint galectin‐9 (Gal‐9) is ...
Cédric Lerévérend, Nour Kotaich, Lucille Cartier, Manon De Boni, Sarah Lahire, Caroline Fichel, Charlotte Thiebault, Eva Brabencova, Célia Maquin, Elodie Barbosa, Laurent Corsois, Judicael Hotton, Sofiane Guendouzen, Philippe Guilbert, Aude‐Marie Lepagnol‐Bestel, Laurence Cahen‐Doidy, Jacqueline Lehmann‐Che, Jérôme Devy, Armand Bensussan, Sébastien Le Jan, Arnaud Pommier, Yacine Merrouche, Richard Le Naour, Stéphane Vignot, Stephane Potteaux   +24 more
wiley   +1 more source

Organoids with cancer stem cell-like properties secrete exosomes and HSP90 in a 3D nanoenvironment [PDF]

, 2018
Ability to form cellular aggregations such as tumorspheres and spheroids have been used as a morphological marker of malignant cancer cells and in particular cancer stem cells (CSC).
Arai, Kazuya, Calderwood, Stuart K., Eguchi, Takanori, Fujiwara, Toshifumi, Iinuma, Ryosuke, Itoh, Manabu, Kozaki, Kenichi, Murakami, Jun, Murata, Yoshiki, Nakano, Keisuke, Nakatsura, Tetsuya, Namba, Yuri, Ohyama, Kazumi, Okamoto, Kuniaki, Okamura, Hirohiko, Okusha, Yuka, Ono, Kisho, Shimomura, Manami, Sogawa, Chiharu, Takigawa, Masaharu, Uchibe, Kenta   +20 more
core   +3 more sources