Results 51 to 60 of about 2,027 (134)
miR-638 mediated regulation of BRCA1 affects DNA repair and sensitivity to UV and cisplatin in triple negative breast cancer [PDF]
, 2014 Introduction Triple-negative breast cancer (TNBC) represents 15 to 20% of all types of breast cancer; however, it accounts for a large number of metastatic cases and deaths, and there is still no effective treatment. The deregulation of microRNAs (miRNAs)
An, Shejuan +9 more
core +2 more sources
Advanced Science, Volume 11, Issue 14, April 10, 2024.This comprehensive review explores recent advancements in intracellular NP delivery, emphasizing the design of personalized nano‐drug‐carriers for clinical applications. It highlights the importance of evaluating drug efficacy and delivery efficiency in physiologically relevant ex vivo human tissue models.
Qiaoxia Zhou +6 more
wiley +1 more source
Journal of Extracellular Vesicles, Volume 13, Issue 3, March 2024.Abstract Extracellular vesicles (EVs), including exosomes and microvesicles, mediate intercellular communication in cancer, from development to metastasis. EV‐based liquid biopsy is a promising strategy for cancer diagnosis as EVs can be found in cancer patients’ body fluids. In this study, the lipid composition of breast cancer‐derived EVs was studied
Erika Dorado +9 more
wiley +1 more source
Distinct EMT programs control normal mammary stem cells and tumour-initiating cells [PDF]
, 2018 Tumour-initiating cells (TICs) are responsible for metastatic dissemination and clinical relapse in a variety of cancers. Analogies between TICs and normal tissue stem cells have led to the proposal that activation of the normal stem-cell program within ...
Kaygusuz, Yasemin +6 more
core +1 more source
Expression of the oncogenes mil and ras abolishes the in vivo differentiation of mammary epithelial cells [PDF]
, 2017 Three carcinoma-associated oncogenes, two of which have been strongly implicated in human mammary tumorigenesis, have been introduced into a novel mouse mammary epithelial cell line, EF43, that retains many differentiated functions.
Günzburg, Walter H. +6 more
core
HOXC8 regulates self-renewal, differentiation and transformation of breast cancer stem cells [PDF]
, 2017 Background: Homeobox genes are master regulators of cell fate during embryonic development and their expression is altered in cancer. By regulating the balance between cell proliferation and differentiation, they maintain homeostasis of normal tissues ...
Allegrucci, Cinzia, +7 more
core +2 more sources
Metallothionein gene expression in human breast cancer [PDF]
, 2003 Metallothioneins (MT) are a family of low molecular weight (6 kDa) cysteine rich proteins that participate in a variety of functions such as detoxification of heavy metals and homeostasis of essential metals.
Gurel, Volkan
core +1 more source
Targeting of Rac GTPases blocks the spread of intact human breast cancer [PDF]
, 2012 High expression of Rac small GTPases in invasive breast ductal carcinoma is associated with poor prognosis, but its therapeutic value in human cancers is not clear.
Caldwell, Helen +6 more
core +1 more source
The role of cavin-1 and caveolin-1 in breast cancer [PDF]
, 2013 Thesis (Ph.D.)--Boston UniversityCaveolae are small invaginations on the plasma membrane of a variety of tissue types and are formed by the caveolin (1 and 2) and cavin (1-3) proteins families.
Honeyman, Brian
core +1 more source