Results 31 to 40 of about 311,821 (303)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Time trends in the prevalence and determinants of age-appropriate breast feeding among children aged 0–23 months in Ghana: a pooled analysis of population-based surveys, 2003–2017

BMJ Open, 2022
Objective We assessed the sociodemographic and maternal–child characteristics associated with age-appropriate breast feeding among children aged 0–23 months in Ghana.Methods We pooled data on 12 743 children aged 0–23 months from three Demographic and ...
Clara Calvert, Judith R Glynn, Laura L Oakley, Milly Marston, Shamsudeen Mohammed   +4 more
doaj   +1 more source

Persistent effects of early infant diet and associated microbiota on the juvenile immune system. [PDF]

, 2015
Early infant diet has significant impacts on the gut microbiota and developing immune system. We previously showed that breast-fed and formula-fed rhesus macaques develop significantly different gut microbial communities, which in turn are associated ...
Ardeshir, Amir, Hartigan-O'Connor, Dennis J, Lu, Ding, Méndez-Lagares, Gema, Narayan, Nicole R, Van Rompay, Koen KA   +5 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Mother–infant interactions and infant intake during breastfeeding versus bottle‐feeding expressed breast milk

Maternal and Child Nutrition, 2021
Bottle‐fed infants are at higher risk for rapid weight gain compared with breastfed infants. Few studies have attempted to disentangle effects of feeding mode, milk composition and relevant covariates on feeding interactions and outcomes.
Alison Ventura, Megan Hupp, Joseph Lavond   +2 more
doaj   +1 more source

Critical Appraisal of Baby Friendly Hospital Initiatives among the beneficiaries of Indore Urban - A Comparative Study [PDF]

, 2009
Background: Majority of the women in M.P who breastfeed their babies throw away the colostrum before they begin actual feed. Only 14.9% females feed their babies with in 1/2 an hour (National Family Health Survey-3). In Indore 2 hospitals have been given
Bhagwat, AK, Chandorkar, RK, Dixit, S, Nigam, R, Sinha, U, Yesikar, V   +5 more
core  

Breast-feeding and childhood hospitalizations for infections [PDF]

, 2010
Background: Infectious disease is a leading cause of morbidity and hospitalization for infants and children. During infancy, breast-feeding protects against infectious diseases, particularly respiratory infections, gastrointestinal infections, and otitis
Kwok, MK, Lam, TH, Leung, GM, Schooling, CM, Tarrant, M   +4 more
core   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

A Randomized Controlled Clinical Trial of Olive Oil Added to Human Breast Milk for Weight Gaining in Very Low Birth Weight Infants

Journal of Family and Reproductive Health, 2011
Objective: Evaluating the effect of vegetable oil, as a supplement to breast milk in increase the weight gaining of VLBW neonates. Materials and methods: In this single blind; Randomized clinical trials , in NICU of Vali-asr Hospital, Tehran University ...
Elaheh Amini, Mamak Shariat, Fatemeh Nayeri, Firoozeh Nili, Bita Ebrahim, Hosein Dalili   +5 more
doaj