Results 91 to 100 of about 2,112,616 (404)

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

Integration of patient-reported outcome measures with key clinical outcomes after immediate latissimus dorsi breast reconstruction and adjuvant treatment

, 2013
Background: linical evidence on patient-reported outcome measures (PROMS) in breast reconstruction is lacking. The aim of this study was to evaluate PROMs in implant-assisted latissimus dorsi (LDI) or tissue-only autologous latissimus dorsi (ALD) flap ...
Balta, V, Benson, J, Betambeau, N, Haviland, J, Prospective Trial Management, Grp, Reece-Smith, A, Winters, Z. E   +6 more
core   +1 more source

Oncoplastic conservative surgery for breast cancer: long-term outcomes of our first ten years experience [PDF]

, 2018
The main goal of oncoplastic breast surgery (OBS) is to optimize cosmetic outcomes and reduce patient morbidity, while still providing an oncologically-safe surgical outcome and extending the target population of conservative surgery.
Barellini, L, Calabrese, C, Casella, D, Di Taranto, G, Fausto, A, Kothari, A, Lo Torto, F, Marcasciano, M, Perra, Agostino, Ribuffo, D, Sordi, S, Tarallo, M   +11 more
core   +1 more source

Complete Surgical Excision Is Essential for the Management of Patients With Breast Implant-Associated Anaplastic Large-Cell Lymphoma.

Journal of Clinical Oncology, 2016
PURPOSE Breast implant-associated anaplastic large-cell lymphoma (BI-ALCL) is a rare type of T-cell lymphoma that arises around breast implants. The optimal management of this disease has not been established.
M. Clemens, L. Medeiros, C. Butler, K. Hunt, M. Fanale, S. Horwitz, D. Weisenburger, Jun Liu, E. Morgan, R. Kanagal-Shamanna, V. Parkash, J. Ning, A. Sohani, J. Ferry, N. Mehta-Shah, A. Dogan, Hui Liu, Nora Thormann, A. Di Napoli, S. Lade, Jorge Piccolini, R. Reyes, T. Williams, C. McCarthy, S. Hanson, L. Nastoupil, R. Gaur, Y. Oki, K. Young, R. Miranda   +29 more
semanticscholar   +1 more source

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

Molecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma, Sophia M. Orbach, Kate V. Griffin, Kathryn Kang, Yining Zhang, Rebecca S. Pereles, Ian A. Schrack, Guillermo Escalona, Jacqueline S. Jeruss, Lonnie D. Shea   +9 more
wiley   +1 more source

Bacterial Adhesion and Biofilm Formation on Textured Breast Implant Shell Materials

Aesthetic Plastic Surgery, 2018
BackgroundBacterial biofilms have been implicated with breast implant complications including capsular contracture and anaplastic large-cell lymphoma. The actual mechanisms for either are still under active investigation and are not clear.
G. James, L. Boegli, John Hancock, Lisa Bowersock, Albert J. Parker, B. Kinney   +5 more
semanticscholar   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Liability in the medical sector : the ‘breast-taking’ consequences of the poly implant prothese case [PDF]

, 2016
The article deals with the liability of third-party certifiers in the medical sector and especially focuses on the role of TuV Rheinland in the recent Poly Implant Prothese (PIP) breast implant case. The aim of the contribution is twofold.
De Bruyne, Jan, Vanleenhove, Cedric
core  

Multiple polyurethane implant punctures during fat grafting: case report and review of the literature

BMC Surgery, 2020
Background Breast augmentation with implants continues to be the most popular aesthetic surgical procedure performed worldwide. Fat grafting may improve the results of breast augmentation and breast reconstruction with implants.
Dmitry Batiukov, V. Podgaiski, D. Mikulich, S. Kalinin   +3 more
doaj   +1 more source

Secondary mammaplasty with monobloc resection and implant repositioning in the partial retropectoral pocket [PDF]

Revista Brasileira de Cirurgia Plástica, 2019
Introduction: Breast augmentation with silicone implants is one of the most common plastic surgery procedures. The objective of this study was to evaluate patients with previous silicone implantations undergoing secondary mammaplasty, presenting an ...
Vinicius Julio Camargo
doaj   +1 more source