Results 111 to 120 of about 1,018,704 (304)

TRIM28‐Derived Peptide Exerts Anti‐Tumor Roles by Stabilizing Tumor Suppressive BRD7 Protein in Multiple Cancers

Advanced Science, EarlyView.
An α‐helical peptide, TAB12, designed to mimic the TRIM28 binding interface, competitively disrupts the TRIM28‐BRD7 interaction, thereby blocking ubiquitin‐mediated degradation of the tumor suppressor BRD7. This stabilization unleashes potent anti‐tumor effects across multiple tumor types with a favorable safety profile, offering a feasible strategy ...
Qingqing Wei, Changning Xue, Mengna Li, Jianxia Wei, Lemei Zheng, Shipeng Chen, Yijie Wang, Yumei Duan, Yanwei Luo, Wei Xiong, Ming Zhou   +10 more
wiley   +1 more source

Breast Cancer Tissue Bank Blood Samples

This BCTB subcollection consists of blood samples taken from breast cancer patients and others. It is further broken down into a number of blood components.

core  

Transcription Factor HOXC11 Drives Colorectal Cancer Progression and Metastasis via CAMK2A‐Dependent CXCL5 Upregulation

Advanced Science, EarlyView.
HOXC11 drives colorectal cancer progression by transcriptionally activating CAMK2A, which triggers NF‐κB–dependent CXCL5 upregulation. CXCL5–CXCR2 signaling further reinforces HOXC11 expression through the ERK1/2–SP1 axis, forming a prometastatic positive feedback loop that is effectively disrupted by combined CAMK2A and CXCR2 inhibition.
Qingyang Sun, Hengjie Xu, Sheng Yang, Jiahui Zhou, Chuanxin Tian, Hongxu Nie, Chi Jin, Tuo Wang, Zhihao Chen, Junwei Tang, Yifei Feng, Xiaowei Wang, Yueming Sun   +12 more
wiley   +1 more source

Evaluating Scopus AI Versus Traditional Searches for Literature Review About Prepectoral Breast Reconstruction: An Exploratory Study

Medical Sciences
Background: Artificial intelligence tools are increasingly being used to assist literature reviews, but their effectiveness compared to traditional methods is not well established.
Ionuț Ștefan Ciule, Ariana-Anamaria Cordos, Răzvan Alexandru Ciocan, Andra Ciocan, Maximilian Vlad Muntean, Claudia Diana Gherman   +5 more
doaj   +1 more source

Silicone Breast Implantation: Doubts about the Fears

, 1995
Silicone gel implantation mammoplasty is a common medical procedure peformed in the United States. In the 1980s, case reports linking a variety of connective tissue diseases and other symptoms with breast implants have appeared.
Brooks, P. M.
core  

Repurposing a Small Molecule Plant Hormone as a Tunable ON‐Switch for CAR‐T Cell Immunotherapy

Advanced Science, EarlyView.
By engineering a receptor system integrating the plant auxin receptor AFB1 with its co‐receptor IAA7, we enable ligand‐dependent interactions triggered by the plant hormone auxins. This design allows rapid, reversible, and dose‐dependent T cell activation, resulting in potent cytotoxicity against B‐cell lymphoma in vitro and in vivo.
Hongxiang Zeng, Lei Zheng, Rongkun Tao, Sirui Zheng, Yanke Zhong, Yongxia Niu, Peng Zhang, Xiang Ma, Chen Yang, Min Zhang, Fuyu Duan, Jing Yang, Xuan Wei, Xiang Zhou, Zhenbiao Yang, Zhaoxi Sun, Qizhou Lian   +16 more
wiley   +1 more source

Breast Cancer Tissue Bank Search Tool

The Research Query page is a component of the Breast Cancer Tissue Bank website. It shows the numbers of consented patients, and the numbers of available samples.

core  

circZNF148 Drives Glucose Metabolism Reprogramming to Enhance Metastasis and Immune Evasion via HK1 Stabilization in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
CircZNF148 stabilizes HK1 through deubiquitinase recruitment, thereby enhancing glycolysis and lactate production. Elevated lactate promotes PD‑L1 lactylation and membrane accumulation while suppressing CD8+ T‐cell cytotoxicity, collectively facilitating immune evasion and malignant progression in TNBC.
Yuhan Jin, Wenjing Zhao, Lei Wang, Jianing Wang, Keying Zhao, Dan Luo, Yifei Wang, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Xiaoyan Li, Bing Chen, Lijuan Wang, Yiran Liang, Qifeng Yang   +17 more
wiley   +1 more source

Complicações em reconstrução mamária total em pacientes mastectomizadas por câncer de mama: análise comparativa de longo prazo quanto a influência de técnica, tempo de cirurgia, momento da reconstrução e tratamento adjuvante

Revista Brasileira de Cirurgia Plástica
INTRODUÇÃO: Algumas técnicas de reconstrução total de mama, independentemente de sua complexidade, apresentam complicações específicas, com diferentes graus de morbidade.
Francisco Claro Jr., Daniela Vieira da Costa, Adivânia de Souza Pinheiro, Aarão Mendes Pinto-Neto   +3 more
doaj   +1 more source

Breast Cancer Tissue Bank Sample and Image Collection

This is a collection of samples of breast cancer and normal breast, also including images of tissue samples, and blood samples. Samples and images are made available from the Breast Cancer Tissue Bank for research into breast cancer including its causes,

core