Results 241 to 250 of about 1,907,433 (308)

A Dual‐Delivery System Designed to Overcome EV‐Mediated Ferroptosis Resistance for Efficient Solid Tumor Therapy

Advanced Science, EarlyView.
(A) Establishment and characterization of the osteosarcoma‐targeted dual‐delivery nanoplatform mBAP1/siENO1@LNP‐OTP for simultaneous regulation of BAP1 and ENO1 in tumor cells. (B) After intravenous administration, mBAP1/siENO1@LNP‐OTP preferentially accumulates at tumor sites through OTP‐mediated targeting.
Yechao Shen, Zhenguo Cao, Zenan Wang, Liang Chen, Jiahao Zhang, Linjie Zeng, Boren Tan, Hengyuan Li, Jiashan Lai, Jiangchu Lei, Fanglu Chen, Peng Lin, Zhenxuan Shao, Zhan Wang   +13 more
wiley   +1 more source

Diagnostic value of contrast-enhanced spectral mammography for breast lesions: qualitative and quantitative analyses. [PDF]

Quant Imaging Med Surg
Guo D, Hao Y, Chang Y, Guo Z, Qian L, Zhang J, Niu J.   +6 more
europepmc   +1 more source

Aged ZnO Nanoparticles Promote Breast Cancer Lung Metastasis by Remodeling the Pulmonary Microenvironment Through the CXCL10/Wnt/β‐Catenin Axis

Advanced Science, EarlyView.
In summary, pulmonary exposure to ZnO NPs, particularly aged NPs, promotes breast cancer metastasis by remodelling the lung tumour microenvironment. Aged ZnO NPs enrich M2‐macrophages, MDSCs and activated CAFs to form an immunosuppressive metastatic niche. CXCL10 from these cells drives metastasis via Wnt/β‐catenin activation.
Yong Zhu, Siyu Wang, Tong Lin, Jingyi Zhang, Jingya Yang, Dixiang Kang, Wenting Zhao, Na Yu, Meimei Wang   +8 more
wiley   +1 more source

High-depth whole genome sequencing of premalignant breast lesions reveals rearrangement hotspots and personalized management opportunities. [PDF]

Nat Commun
Chmelova L, Davies HR, Degasperi A, Rinaldi G, Wils L, Black D, Memari Y, Koh GCC, Shooter S, Mulder L, Kristel P, Szuhai K, Prasad G, Wong IT, Luebeck J, Kumar Y, Czarnecki J, Basyuni S, Kingsbury Z, Ross MT, Garred Ø, Riis M, Lande KT, Vallon-Christersson J, Ehinger A, Agrawal A, McIntosh SA, Bafna V, Mischel PS, Grand Challenges PRECISION Consortium, Wesseling J, Staaf J, Sørlie T, Lips EH, Nik-Zainal S.   +34 more
europepmc   +1 more source

Intratumoral Fusogenic Outer Membrane Vesicles Enhance Antitumor Immunity Through Tumor MHC‐I Upregulation and Tumor Bacterization

Advanced Science, EarlyView.
Tumor bacterization by fusogenic outer membrane vesicles enhances microbial‐like recognition of tumor cells while activating the TLR4–NF‐κB–NLRC5 axis to upregulate MHC class I expression. By simultaneously strengthening APC sensing and T‐cell recognition, this strategy breaks tumor immune invisibility and promotes more effective antitumor immune ...
Xing Liu, Jiaxin Zhou, Guihong Lu, Chenjing Zhao, Weixiu Wang, Jichuan Chen, Fengqi Zhang, Fan Zhang, Hai‐Yan Xie, Weidong Nie   +9 more
wiley   +1 more source

Histomorphological Changes in Breast Lesions: A Retrospective Observational Study. [PDF]

Cureus
Chaudhari P, Srivastav S, Gupta S, Syed N, Sanker V, Vora NM, Venugopal L, Mane R.   +7 more
europepmc   +1 more source

RBMS1 Contributes to Early Arteriovenous Fistula Neointimal Remodeling Through Modulation of VSMC Phenotypic Responses

Advanced Science, EarlyView.
Postoperative arteriovenous fistulas exhibit increased RBMS1 in vascular smooth muscle cells (VSMCs). In experimental AVFs, RBMS1 overexpression aggravates, whereas deletion attenuates, neointimal hyperplasia. RBMS1 binds MPZL1 mRNA and promotes exon 5 skipping to generate MPZL1‐Δ5, which interacts with G3BP1 to activate AKT, driving VSMC proliferation,
Zongda Li, Chengwei Zhang, Xinying Yu, Shuang Yao, Yiting Lai, Xiaozhu Sun, Yao Zhao, Xiaoyu Lan, Tingting Hu, Wenjin Li, Zhenzhen Ma, Huimin Ma, Zihan Wang, Haihai Liang, Jundong Jiao   +14 more
wiley   +1 more source

Budget Impact Analysis of Vacuum-Assisted Excision Versus Surgical Excision for the Assessment of Breast Lesions of Uncertain Malignant Potential in Italy. [PDF]

Pharmacoecon Open
Rognoni C, Cavallaro L, Grassi G, Caumo F, Depretto C, Folli S, Minelli S, Pezzella M, Rocco N, Romeo V, Russo A, Scaperrotta G, Tarricone R.   +12 more
europepmc   +1 more source

Enhancing mixed solid and cystic breast lesions diagnosis: a simplified scoring system integrating ultrasound features and clinical factors. [PDF]

BMC Med Imaging
Jia Y, Lan Q, Liu T, Zhu Y, Cao C, Hu X, Nie F.   +6 more
europepmc   +1 more source