Results 161 to 170 of about 404,237 (268)

Targeting p21‐High Senescent Kupffer Cells Nanotherapeutically Potentiates Antitumor Immunity in Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombus

Advanced Science, EarlyView.
Schematic illustration of a biomimetic SKEV@AAV platform targeting p21‐high senescent Kupffer cells (sKCs) in hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT). p21‐high sKCs accumulate in the PVTT microenvironment and establish an immunosuppressive, SASP‐rich environment that facilitates tumor cell proliferation and immune evasion.
Na Ta, Shuyi Wang, Boyan Zhang, Ning Liu, Yingchen Han, Aoran Liu, Ying Xu, Tingsong Chen, Ye Zhang, Qiuhua Luo, Tao Han   +10 more
wiley   +1 more source

Renal Cell Carcinoma in Pregnancy With Breast Metastasis: A Case Report and Literature Review. [PDF]

Cureus
Aslan F, Erkılıç B, Türkmen G, Günaydın E, Hasanov C.   +4 more
europepmc   +1 more source

Male Breast Metastasis: A Case of Treatment-Emergent Neuroendocrine Prostate Cancer. [PDF]

Cureus, 2022
Sismeiro R, Brito Monteiro M, Negrão C, Tomás T, Jonet M.   +4 more
europepmc   +1 more source

EpCAM+ Extracellular Vesicle PD‐L1 Dynamics as a Predictive Biomarker of Immune Checkpoint Blockade Response

Advanced Science, EarlyView.
A highly sensitive SERS‐based platform measures PD‐L1 expression on EpCAM+ circulating EVs from cancer patients undergoing immunotherapy. Monitoring dynamic changes after treatment reveals that reduced EpCAM+ EV PD‐L1 levels associate with improved long‐term clinical outcomes, establishing a non‐invasive approach for tracking immune checkpoint ...
Byeonggeol Mun, Jinyoung Kim, Chang Gon Kim, Seokhyeong Go, Mina Han, Yujin Ouck, Soojin Jang, Seong Uk Son, Gamin Kim, Wonrak Son, Eunjung Kim, Min Hee Hong, Ja Hyun Yeo, Eun‐Kyung Lim, Hye Ryun Kim, Seungjoo Haam   +15 more
wiley   +1 more source

Rare Breast Metastasis From Urothelial Carcinoma: A Case Report and Literature Review. [PDF]

Cureus
Mohamed T, Elhashamy H, Ramez M, Bickers A, Phull J.   +4 more
europepmc   +1 more source

Imaging Findings of Breast Metastasis from Malignant Peripheral Nerve Sheath Tumor of Mediastinum: A Case Report. [PDF]

J Korean Soc Radiol, 2023
Park SH, Park JY, Joo M.
europepmc   +1 more source

ANXA2+ Small Extracellular Vesicles Drive Chemoresistance in Anaplastic Thyroid Cancer by Promoting XRCC5 Lactylation and Enhancing Non‐Homologous End‐Joining Repair

Advanced Science, EarlyView.
ANXA2+ sEVs promote cisplatin resistance in ATC by stabilizing the SRC/LDHA interaction, increasing LDHA phosphorylation and activity, and lactate production. Elevated lactate levels promote KAT5‐mediated lactylation of XRCC5 at lysine 265, enhancing its binding to XRCC6.
Shanshan Su, YiShan Xiong, Yuxuan Liang, Xiang Min, Daofeng Dai   +4 more
wiley   +1 more source

Multiple Myeloma Presenting as Breast Metastasis: Diagnostic Challenges and Case Analysis. [PDF]

Am J Case Rep
Messina G, Fucile MA, Kupper M, Campitiello M, Plastino F, Legros PO, Egea J, Carassou P, Tortora G, Longo R.   +9 more
europepmc   +1 more source

Breast metastasis 18 years after nephrectomy for renal cell carcinoma: a case report. [PDF]

J Surg Case Rep, 2022
Elouarith I, Bouhtouri Y, Elmajoudi S, Bekarsabein S, Ech-Charif S, Khmou M, Messaoudi H, Mahdi Y, Hachi H, El Khannoussi B.   +9 more
europepmc   +1 more source

Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy

Advanced Science, EarlyView.
A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li, Daishi Li, Danyao Chen, Yating Dian, Lei Yao, Hui Su, Ziyu Guo, Deze Zhao, Zihua Wu, Furong Zeng, Chunfang Zhang, Guangtong Deng   +11 more
wiley   +1 more source