Results 191 to 200 of about 1,744,838 (315)

A single-arm study to evaluate the transfer of drospirenone to breast milk after reaching steady state, following oral administration of 4 mg drospirenone in healthy lactating female volunteers [PDF]

, 2020
Dace Melka, Kalev Kask, Enrico Colli, Pedro‐Antonio Regidor   +3 more
openalex   +1 more source

Polystyrene Microplastics Exposure Aggravates Clear Cell Renal Cell Carcinoma Progression via the NF‐κB and TGF‐β Signaling Pathways

Advanced Science, EarlyView.
This research provides the first comprehensive evidence that PS‐MPs exacerbate ccRCC progression by activating the NF‐κB and TGF‐β pathways. These findings establish PS‐MPs as an environmental risk factor for ccRCC progression and identify the NF‐κB and TGF‐β signaling as potential therapeutic targets to mitigate the adverse effects of ‐PS‐MPs exposure.
Shiqi Ye, Jianfeng Xiang, Siqi Zhou, Qintao Ge, Aihetaimujiang Anwaier, Kun Chang, Gang Wei, Jiahe Lu, Xi Tian, Shuxuan Zhu, Yuchen Jiang, Wei Zhang, Tingting Cai, Moran Xu, Dingwei Ye, Danfeng Xu, Tao Wang, Hailiang Zhang, Wenhao Xu   +18 more
wiley   +1 more source

Microbiome Profiling of Pretreated Human Breast Milk Using Shotgun Metagenomic Sequencing. [PDF]

J Microbiol Biotechnol
Zhang Q, Zhang Y, Zhu J, Gao Y, Zeng W, Qi H.   +5 more
europepmc   +1 more source

Tumor Extracellular Vesicles lncOSLMT Drives Lung Inflammatory Premetastatic Niche Formation in Osteosarcoma via m6A‐Dependent hnRNPA2B1/COX‐2 Axis

Advanced Science, EarlyView.
Tumor‐derived extracellular vesicles program inflammatory lung premetastatic niches through selective delivery of long noncoding RNAs. This work reveals EVs‐associated lncOSLMT as a key driver of lung fibroblast activation via m6A‐dependent PTGS2 stabilization.
Hongbo Li, Zehao Guo, Yutong Zou, Jiongfeng Zhang, Jixiang Shi, Xihong Fu, Jian Tu, Hao Yao, Xuanxuan Lu, Lili Wen, Xianbiao Xie   +10 more
wiley   +1 more source

Need of the hour? does breast milk bank reduces perinatal morbidity and mortality: a retrospective observational study

, 2020
E. K. Narayanan, Mohd Sajjid, Arun Kumar
openalex   +2 more sources

Multimodal AI‐Driven Identification of Dehydrocostus Lactone as a Potent Renal Fibrosis Attenuator Targeting IQGAP1

Advanced Science, EarlyView.
Renal fibrosis, a hallmark of CKD, lacks effective treatments. Herein, we developed a multimodal AI model (TCM‐SPred) to identify anti‐fibrotic agents and found that dehydrocostus lactone (DCL) targets IQGAP1 to inhibit Wnt signaling, blocking the interaction between IQGAP1 and CCT3, demonstrating potent anti‐fibrotic activity in vitro and in vivo ...
Weijiang Lin, Wenzhuo Xu, Kang Liu, Ping Wang, Zhenzhen Zhu, Wenyu Lu, Zhe Zheng, Xiaoqian Peng, Xunkai Yin, Shulan Mei, An Pan, Jian Liu, Lihong Hu   +12 more
wiley   +1 more source

Differential microRNAs and metabolites in the breast milk of mothers with adverse childhood experiences. [PDF]

Transl Psychiatry
Tomaszewska W, Apanasewicz A, Gomółka M, Matyas M, Rojek P, Szołtysik M, Babiszewska-Aksamit M, Gielniewski B, Wojtas B, Ziomkiewicz A, Jawaid A.   +10 more
europepmc   +1 more source

Residual congener pattern of dioxins in human breast milk in southern Vietnam

, 2011
Kenji Tawara, Muneko Nishijo, Shoko Maruzeni, Hideaki Nakagawa, Teruhiko Kido, Rie Naganuma, Hiroyuki Suzuki, Dang Duc Nhu, Nguyễn Ngọc Hưng, Le Thi Thom   +9 more
openalex   +2 more sources

Women’s Plasma Phospholipid DHA Concentration Directly Relates to Breast Milk and Infant DHA Status in the Alberta Pregnancy Outcomes and Nutrition Study

, 2020
Catherine J. Field, Susan Goruk, Nour Wattar, Mohammadreza Pakseresht   +3 more
openalex   +1 more source

Targeted Degradation of eEF2K by a Structure‐Guided PROTAC Strategy for the Treatment of Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study developed an eEF2K‐targeting PROTAC, A6, that efficiently degrades eEF2K in TNBC cells, inhibiting tumor growth in vitro and in vivo. To enhance tumor‐specific delivery, we engineered A6@ZIF‐8, a pH‐sensitive nanocarrier, which improved drug accumulation at tumor sites, offering a promising therapeutic strategy for TNBC through targeted ...
Shijun Cao, Changxin Zhong, Shilong Jiang, Yungui Li, Yang Xi, Mingxuan Xiao, Ting Jiang, Xiaoya Wan, Zonglin Chen, Xiaohui Yu, Yan Cheng   +10 more
wiley   +1 more source