The Role of CAF‐derived Vitronectin in Promoting Colorectal Cancer Progression and Immunosuppression
Cancer‐associated fibroblast (CAF)‐derived VTN upregulates SLC6A8 expression in colorectal cancer (CRC) cells and macrophages through enhanced FAK phosphorylation. This modulation significantly increases the cellular uptake of creatine and ATP, promoting cancer progression and macrophage polarization.
Jiahua Yu+5 more
wiley +1 more source
Are breast milk and serum irisin levels affected by the BMI and nutritional status? A prospective observational study. [PDF]
Yilmaz FÇ, Türkoğlu S, Erman F.
europepmc +1 more source
1483 HUMAN MILK LIPASE ASSOCIATED WITH BREAST MILK JAUNDICE: SUBSTRATE SPECIFICITY [PDF]
Ronald L. Poland, Roger Williams
openalex +1 more source
This study reveals a new mechanism by which PDIA3P1 regulates the progression of esophageal squamous cell carcinoma (ESCC). PDIA3P1 upregulates the expression of GLUT1 and HK2, promoting glycolysis and lactate production. Lactate upregulates the lactylation level of histone H4K8 and activates the transcription of target gene BMP7, ultimately ...
Tao Huang+13 more
wiley +1 more source
Individualized Target Fortification of Breast Milk with Protein, Carbohydrates, and Fat for Preterm Infants: Effect on Neurodevelopment. [PDF]
Rochow N+8 more
europepmc +1 more source
EFFECT OF BANKED HUMAN BREAST MILK(BHBM) ON THE POST-NATAL EVOLUTION OF MIDARM CIRCUMFERENCE (MAC), TRICIPITAL (T), AND SUBSCAPULAR(S) SKINFOLD (SKF)THICKNESS, ARM MUSCLE(AMA) AND FAT AREAS (AFA) IN APPROPRIATE(AGA) AND SMALL FOR GESTATIONAL AGE(SGA) VERY LOW BIRTH-WEIGHT INFANTS (VLBW) [PDF]
Jean‐Louis Excler+3 more
openalex +1 more source
Spatiotemporal Adaptations‐Driven Dynamic Thra Activation Simulates a Skin Wound Healing Response
This study uncovers the thyroid hormone receptor Thra as a pivotal regulator that spatiotemporally orchestrates dual‐phase skin repair. Epidermal Thra accelerates barrier restoration via glutathione‐driven keratin assembly, while dermal Thra establishes angiogenic niches through SAA3‐FN1‐mediated matrix remodeling.
Zeming Li+15 more
wiley +1 more source
An Integrative Review of Exclusive Breast Milk Expression. [PDF]
Rosenbaum K, McAlister B.
europepmc +1 more source
Rapamycin alleviates heart failure via TFEB and CaMKII pathways in Syntaxin 12/13 deficient models. Stx12 deficiency causes heart failure via impaired iron trafficking to mitochondria, reducing respiratory complexes and sarcoplasmic reticulum Ca2+‐ATPase (SERCA).
Run‐Zhou Yang+12 more
wiley +1 more source