Results 301 to 310 of about 1,935,876 (396)

First‐in‐Human Study of Merotocin, a Short‐Acting Peptidic Oxytocin Receptor Agonist for Lactation Support

open access: yesClinical Pharmacology in Drug Development, EarlyView.
Abstract Endogenous oxytocin plays an important role in lactation, but its effectiveness as an exogenous galactagogue has been modest due to dose‐limiting side effects related to off‐target effects at the vasopressin V2 receptor. Merotocin (FE 202767) is a short‐acting peptidic oxytocin receptor agonist with the potential to aid mothers experiencing ...
Yu Bagger   +4 more
wiley   +1 more source

Rules of Thumb for Estimating Drug Levels in Breast Milk: How Well Do They Work?

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
The American Academy of Pediatrics and the World Health Organization recommend exclusive breastfeeding for the first 6 months of life due to extensive benefits for the maternal–infant dyad. While over 90% of mothers initiate breastfeeding, continuation drops to 35% by 6 months, often due to concerns about medication safety.
Juliya Gasparyan   +3 more
wiley   +1 more source

Decoding anthracycline‐ and trastuzumab‐related cardiac dysfunction prediction: HFA‐ICOS scores versus strain imaging

open access: yesESC Heart Failure, EarlyView.
Left ventricular global longitudinal strain (LV‐GLS) is the best tool for predicting CTRCD due to anthracycline and trastuzumab. Abstract Aims Baseline Heart Failure Association–International Cardio‐Oncology Society (HFA‐ICOS) scores and serial left ventricular global longitudinal strain (LV‐GLS) measurements have been found to be useful in predicting ...
Hai Hoang Nguyen   +4 more
wiley   +1 more source

Infant respiratory infections modulate lymphocyte homing to breast milk. [PDF]

open access: yesFront Immunol
Zheng Y   +7 more
europepmc   +1 more source

Peptide RL‐QN15 Regulates Functions of Epidermal Stem Cells to Accelerate Skin Wound Regeneration via the FZD8/β‐Catenin Axis

open access: yesExploration, EarlyView.
Amphibian‐derived peptide RL‐QN15 activates the Wnt/β‐catenin signaling pathway by interacting with the FZD8 membrane receptor, promoting epidermal stem cells proliferation, migration, stemness, and EMT processes, thus promoting skin wound healing.
Yuansheng Li   +15 more
wiley   +1 more source

Extracellular Vesicle‐Based mRNA Therapeutics and Vaccines

open access: yesExploration, EarlyView.
This review provides a comprehensive analysis of recent advancements in extracellular vesicle (EV)‐based messenger RNA (mRNA) applications for therapeutics and vaccines. It systematically outlines strategies for mRNA encapsulation within EVs and elucidates the challenges associated with this technology, offering insights into future research directions
Qi Li   +6 more
wiley   +1 more source

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