Results 81 to 90 of about 7,036,024 (258)

Crosstalk Between CTSB+ Glioblastoma Cells and S100A10+ Macrophages: A Self‐Reinforcing Circuit Promotes Immune Evasion and Limits Response to Immunotherapy

Advanced Science, EarlyView.
In glioblastoma, M2‐polarized macrophages secrete IL‐6, which activates STAT3 signaling in tumor cells to upregulate CTSB. Tumor‐derived CTSB binds the C‐terminus of macrophage S100A10, reinforcing M2 polarization and further IL‐6 secretion, thereby establishing a feedforward IL‐6/STAT3/CTSB/S100A10 loop. This cascade drives tumor growth, invasion, and
Hao Zhang, Nan Zhang, Xisong Liang, Jie Wen, Ziyu Dai, Wantao Wu, Shuyu Li, Songshan Feng, Zaoqu Liu, Zhiwei Xia, Peng Luo, Quan Cheng   +11 more
wiley   +1 more source

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

Advanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi, Lin Yang, Kang‐Li Wang, Hui‐Zhu Liu, Rui‐Ying Chen, Min Su, Xiao Xiao, Yu‐Qiu Zhang   +7 more
wiley   +1 more source

SARI KACANG HIJAU SEBAGAI ALTERNATIF MENINGKATKAN PRODUKSI AIR SUSU IBU (ASI) PADA IBU MENYUSUI

Jurnal Keperawatan dan Fisioterapi, 2019
Nursing mothers belong to one of the vulnerable groups of nutrition, because breast milk which is the main food for babies is obtained from the mother. Therefore, mothers who are breastfeeding must be controled to the intake of nutrients consumed.
Nikmah Jalilah Ritonga, Eka Defi Mulyani, Diah Evawanna Anuhgera, Damayanti Damayanti, Riris Sitorus, Wilda Wahyuni Siregar   +5 more
doaj   +1 more source

Effects of Maternal Stress on Breast Milk Production and the Microbiota of Very Premature Infants. [PDF]

Nutrients, 2023
Fernández-Tuñas MDC, Pérez-Muñuzuri A, Trastoy-Pena R, Pérez Del Molino ML, Couce ML.   +4 more
europepmc   +1 more source

GM‐CSF Promotes Neutrophil PD‐L1 Expression Through the VEGFR‐2/STAT6/CSF2 Signaling Axis in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
VEGFR‐2 signaling in OSCC activates Src–STAT6‐dependent CSF2 transcription, driving tumor‐derived GM‐CSF secretion. GM‐CSF programs neutrophils to express PD‐L1 through STAT5–mTOR/S6K signaling, suppressing cytotoxic CD8+ T cells. This pathway reveals a tumor–neutrophil immune checkpoint circuit that limits anti‐PD‐1 responsiveness in OSCC.
Fangxing Zhu, Yuanhe You, Yiyi Zhang, Yibin Dai, Xinyu Zhou, Yong Fu, Xi Lu, Yingying Huang, Zhihang Zhou, Ronghui Xia, Wutong Ju, Zhaoqi Yuan, Laiping Zhong, Tongchao Zhao   +13 more
wiley   +1 more source

Lanthanum Carbonate Nanosheets Based Colloidal Hydrogel for Modulating Innate & Adaptive Tumor Immunotherapy by Augmented Cellular Pyroptosis

Advanced Science, EarlyView.
The Gela/decitabine/La2(CO3)3 colloidal (GDLC) hydrogel developed here could reverse the epigenetic silencing of the GSDME gene by the synergistic interaction between DAC and La3+, while concurrently activating caspase‐3, thus facilitating pyroptosis induction under the tumor microenvironment.
Yang Hong, Haitao Wu, Weitao Wang, Xuan Zhang, Qian Chen, Yaoyu Hu, Zhengbao Zha   +6 more
wiley   +1 more source

EFFECT OF MUSA BALBISIANA COLLA EXTRACT ON BREAST MILK PRODUCTION IN BREASTFEEDING MOTHERS

Belitung Nursing Journal, 2017
Background: Musa balbisiana Colla, known as Jantung Pisang Klutuk/Pisang Batu, is considered as a traditional food that can increase breast milk production. Little is known about its benefit in Indonesia.
Diyan Wahyuningsih, Syarief Taufik Hidayat, Nur Khafidhoh, Ari Suwondo, iyah Fatmasari, Kun Aristiati Susiloretni   +5 more
doaj  

Infant morbidity, mortality, and breast milk immunologic profiles among breast-feeding HIV-infected and HIV-uninfected women in Botswana.

, 2007
BACKGROUND: Infants of human immunodeficiency virus (HIV)-infected women have high mortality, but the immunologic integrity and protection afforded by the breast milk of HIV-infected women is unknown.
Rahkola, Jeremy T, Shapiro, Roger L, Janoff, Edward N, Stevens, Lisa, Smeaton, Laura, Wester, Carolyn, Arimi, Peter, Ndase, Patrick, Makhema, Joseph, Montano, Monty, Asmelash, Aida, Lockman, Shahin, Thior, Ibou, Kim, Soyeon, Moffat, Claire, Essex, Max   +15 more
core   +1 more source

TRIM28‐Derived Peptide Exerts Anti‐Tumor Roles by Stabilizing Tumor Suppressive BRD7 Protein in Multiple Cancers

Advanced Science, EarlyView.
An α‐helical peptide, TAB12, designed to mimic the TRIM28 binding interface, competitively disrupts the TRIM28‐BRD7 interaction, thereby blocking ubiquitin‐mediated degradation of the tumor suppressor BRD7. This stabilization unleashes potent anti‐tumor effects across multiple tumor types with a favorable safety profile, offering a feasible strategy ...
Qingqing Wei, Changning Xue, Mengna Li, Jianxia Wei, Lemei Zheng, Shipeng Chen, Yijie Wang, Yumei Duan, Yanwei Luo, Wei Xiong, Ming Zhou   +10 more
wiley   +1 more source

Changes in R0/R∞ ratio and membrane capacitance are associated with milk removal from the breast.

PLoS ONE, 2018
Perceived low milk supply is a common reason for introducing supplementary feeds, which in turn serves to further diminish the milk supply. Current methods of measuring milk production and milk transfer from the breast to the infant are inaccessible to ...
Hazel Gardner, Ching Tat Lai, Leigh Ward, Donna Geddes   +3 more
doaj   +1 more source