Results 91 to 100 of about 2,016,148 (297)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
A clinical diagnostic test on the detection of sentinel lymph node metastasis in breast neoplasms using a 1-step RT-PCR. [PDF]
Gland Surg, 2022 Shang J +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Syntaxin-1 and Insulinoma-Associated Protein 1 Expression in Breast Neoplasms with Neuroendocrine Features. [PDF]
Pathol Oncol Res, 2021 Turkevi-Nagy S +5 more
europepmc +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
An investigational protocol of intraoperative radiotherapy in the treatment of early-stage breast cancer: partial results from the Hospital Israelita Albert Einstein [PDF]
Einstein (São Paulo), 2007 Objective: To describe and assess the experience of the HospitalAlbert Einstein on the treatment of early-stage breast cancer withintraoperative radiotherapy. Methods: Twenty-two patients withinvasive breast cancer, older than 45 years, with tumors ≤ 2.5
Silvio Eduardo Bromberg +7 more
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Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Comprehensive Analysis of Clinicopathologic Features and p53 Mutation in Neuroendocrine Neoplasms of the Breast: Experience from a Large Academic Center [PDF]
, 2022 Saba Shafi +4 more
openalex +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
BREAST TUMOR (PAPILLOMA) IN A PREGNANT WOMAN (CLINICAL CASE)
Мать и дитя в КузбассеThe weakly positive Rh factor (Du phenotype) was described by The cause of neoplasms is the human papillomavirus (HPV), which infects about 80% of the world's population.
Светлана Ивановна Елгина +4 more
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