Results 201 to 210 of about 6,087,224 (375)
The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity
We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda+9 more
wiley +1 more source
Treatment of Bicalutamide-Induced Gynecomastia With Breast-Reduction Surgery in Prostate Cancer [PDF]
Mari Nakabayashi+2 more
openalex +1 more source
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić+3 more
wiley +1 more source
Vertical Breast Reduction Mammaplasty in the Adolescent Population. [PDF]
Rogers AE+9 more
europepmc +1 more source
The Superomedial Pedicle Wise-Pattern Breast Reduction: Reproducible, Reliable, and Resilient
Rodger H. Brown+3 more
semanticscholar +1 more source
TTT and R2TP chaperone complexes are required for the assembly and activation of mTORC1. WAC directly interacts with components of TTT, R2TP, and mTORC1, and these interactions are affected by the availability of glucose and glutamine, correlating with changes in mTORC1 activity.
Sofía Cabezudo+11 more
wiley +1 more source
Lifestyle Change Including Dietary Fat Reduction and Breast Cancer Outcome [PDF]
Rowan T. Chlebowski
openalex +1 more source
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr+5 more
wiley +1 more source
Lactobacillus fermentum CECT 5716 and a reduction of the Staphylococcus load in breast milk which reduces the risk of infectious mastitis:evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006 [PDF]
core +1 more source