Results 71 to 80 of about 540,622 (219)

Presenting for Duty

Annals of Surgery Open, 2020
Roshni Rao, MD, Luona Sun, MD, Charise Acevedo, Ana Concepcion, BA, Dionisia Concepcion, Josenny Sanchez, MHA, Catherine Alicea, RN, Lisa Franco, RN, Rosanna Frias, Adrianna Flores, Armisia Vega, Jennifer Baez, AAS, Nancy Soler, Sylvia Alvarez, BA, Bret Taback, MD, Madhu Rao, PhD, Lisa Wiechmann, MD   +16 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Mendelian randomization analysis reveals the causal relationship between immune cells and leukemia

Discover Oncology
Background Increasing evidence indicates certain types of immune cells are linked to leukemia, but whether this link is causal has remained unclear.
Yaobin Lin, Shenghong Shi, Jianyuan Song, Shan Liu   +3 more
doaj   +1 more source

Adherence to adjuvant endocrine therapy including GnRH-analogues and survival: a population-based cohort studyResearch in context

EClinicalMedicine
Summary: Background: Adjuvant endocrine therapy (AET) combining gonadotropin-releasing hormone analogues (GnRHa) with tamoxifen (TAM) or aromatase inhibitors (AI) improves survival in premenopausal women with breast cancer compared to TAM and is ...
Louise Eriksson Bergman, Alexios Matikas, Xingrong Liu, Theodoros Foukakis   +3 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Prognostic role of STMN1 expression and neoadjuvant therapy efficacy in breast cancer

BMC Cancer
Purpose breast cancer is common and highly malignant, currently, STMN1 was found to be associated with several human malignancies. The purpose of this study is to investigate STMN1 expression in breast cancer and explore its role in disease progression ...
Li Qian, Zhu Cairong, Liao Yongdong, Li Quan, Zhong Haihu, Zhu Xiaofeng, Ye Xuan, Chen Yongcheng, Chen Kai, Lu Guanming, Li Jie   +10 more
doaj   +1 more source

Miejsce atezolizumabu w leczeniu chorych na niedrobnokomórkowego raka płuca w starszym wieku – nowe możliwości i wyzwania

Oncology in Clinical Practice
Rak płuca pozostaje wiodącą przyczyną zgonów z powodu chorób nowotworowych, a większość zachorowań na niedrobnokomórkowego raka płuca (NDRP) dotyczy osób w starszym wieku.
Magdalena Knetki-Wróblewska, Katarzyna Broczek, Damian Tworek, Izabela Chmielewska, Dariusz M. Kowalski, Maciej Krzakowski   +5 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source