Results 191 to 200 of about 172,225 (297)

Dual Targeting of Tau Kinases and Autophagy by Abemaciclib Independent of CDK4/6 Inhibition

Advanced Science, EarlyView.
Abemaciclib rescues cognitive function and attenuates tau pathology in Alzheimer's disease models, but not through its known cancer‐fighting mechanism. This study demonstrates that abemaciclib operates independently of CDK4/6 inhibition, instead directly targeting tau kinases CaMKII and GSK3β while simultaneously promoting autophagic clearance of ...
Jihui Han, June‐Hyun Jeong, Dongjoon Lee, Yujin Jung, Yujin Jin, Eun Sun Jung, Haeng Jun Kim, Woo Youn Kim, Chang‐Han Lee, Inhee Mook‐Jung   +9 more
wiley   +1 more source

Genetic diversity and population structure of U.S. Suffolk sheep participating in the national sheep improvement program. [PDF]

Genet Sel Evol
Wilson CS, Murdoch BM, Brito LF, Taylor JB, Rocha AO, Freking BA, Murphy TW, Lewis RM.   +7 more
europepmc   +1 more source

Preferential Analysis of Sheep Breeds Among Consumers and Cattle Traders Prior to the 2024 Qurban Celebration

Ken Ratu Gharizah Alhuur, Denie Heriyadi
openalex   +2 more sources

Astrocytic PCBP1 Suppresses Ferroptosis to Restore Glutamatergic Homeostasis and Mitigate Stress‐Induced Depression in Male Mice

Advanced Science, EarlyView.
This study demonstrates that polyC‐RNA‐binding protein 1 (PCBP1) in ventral hippocampal astrocytes modulates depressive‐like behaviors by regulating glutathione peroxidase 4‐mediated ferroptosis and synaptic glutamatergic transmission. PCBP1 overexpression intervention in the chronic unpredictable mild stress model rescues behavioral deficits ...
Jinyu Zhang, Binbin Zhao, Min Jia, Yan Zhao, Ye Lu, Wenyu Xi, Ziyu Zhu, Xiaojuan Gong, Qingyan Ma, Yuan Gao, Yijie Guo, Pan Li, Feng Zhu, Shuguang Wei, Xiancang Ma, Yunpeng Wang   +15 more
wiley   +1 more source

Every Tumour Counts: A Comprehensive Overview of Canine Oncology in Portugal. [PDF]

Animals (Basel)
Brilhante-Simões P, Lopes R, Delgado L, Silva A, Pires I, Marcos R, Queiroga F, Prada J.   +7 more
europepmc   +1 more source

Effects of transportation induced stress in electrocardiography data and blood parameters in Kangal Akkaraman sheep breed

, 2019
Mustafa KOÇKAYA
openalex   +2 more sources

Data on anatomy, movement, and foraging behaviour of three cattle breeds of different productivity

, 2020
Caren M. Pauler, J. Isselstein, Joël Bérard, Thomas Braunbeck, Manuel K. Schneider   +4 more
openalex   +1 more source

Autopolyploidization‐Induced Chromatin Remodeling Regulates Leaf Size Variation in Brassica rapa

Advanced Science, EarlyView.
This study demonstrates that monoploid, diploid, and autotetraploid Brassica rapa lines derived from the same genome exhibit distinct leaf morphology. Ploidy changes remodel chromatin accessibility and histone modifications to regulate gene expression, while key transcription factors BrGRF13 and BrARF11 control leaf size and polarity, driving ...
Haoyuan Dong, Yanhong Liu, Yuanming Liu, Shuxin Xuan, Huanhuan Chen, Lai Wei, Guibao Zhang, Hongcui Pei, Zilong Dai, Yanhua Wang, Jinzhu Qiao, Shuangxia Luo, Xueping Chen, Yiguo Hong, Jianjun Zhao, Shuxing Shen, Zefu Lu, Aixia Gu   +17 more
wiley   +1 more source

Shade matters: heat stress alleviation in Gyr and Girolando cows through silvopastoral management in tropical conditions. [PDF]

Int J Biometeorol
McManus C, Pimentel F, Junqueira VS, Balbino LC, Cordeiro LAM, Bernal F, Peripolli V, Ferreira IC.   +7 more
europepmc   +1 more source

Effectiveness of Multivitamins vs Folic Acid on Prevention of Neural Tube Defects in Mouse Genetic Models and Human Organoids

Advanced Science, EarlyView.
Folic acid (FA) and multivitamins/minerals (MVM) are recommended for the prevention of neural tube defects (NTDs). Using a novel human neural tube‐like organoid system and mouse models, the study compares the effectiveness of two supplements on NTDs and cellular behaviors.
Huili Li, Jing Zhang, Lori Bulwith, Lee Niswander   +3 more
wiley   +1 more source