Results 281 to 290 of about 680,742 (343)

Crafting the Organic–Inorganic Interface with a Bridging Architecture for Solid‐State Li‐O2 Batteries

open access: yesAdvanced Science, EarlyView.
Through the strategic incorporation of functionalized silane coupling agents within the electrolytic matrix, a pioneering methodology is demonstrated that facilitates the formation of molecular bridges across the organic/inorganic heterogeneous interface.
Minghui Li   +7 more
wiley   +1 more source

Risk Factors for the Occurrence of Cutaneous Neoplasms in Dogs: A Retrospective Study by Cytology Reports, 2019-2021. [PDF]

open access: yesAnimals (Basel)
García-Reynoso IC   +7 more
europepmc   +1 more source

RelA Inhibits Embryonic Myogenesis by Coordinately Regulating a Novel Distal Enhancer of Myogenin

open access: yesAdvanced Science, EarlyView.
Maternal obesity (MO) accounts for more than 40% of pregnancies in the United States, induces inflammation, and impairs embryonic myogenesis, known to program muscle dysfunction in offspring. Inflammation enhances the binding of RelA to a novel distal enhancer located 4 kb upstream of myogenin promoter to inhibit embryonic myogenesis, which is ...
Md Nazmul Hossain   +9 more
wiley   +1 more source

Neutrophil Mobilization Triggers Microglial Functional Change to Exacerbate Cerebral Ischemia‐Reperfusion Injury

open access: yesAdvanced Science, EarlyView.
These study underscores the pivotal role of neutrophil‐derived myeloid‐related protein 14 (MRP14) in the pathophysiology of acute ischemic stroke (AIS). MRP14 not only disrupts mitochondrial function, thereby inhibiting microglial phagocytosis of neutrophils, but also activates microglial pyroptosis, exacerbating neuroinflammation following AIS ...
Huijuan Jin   +10 more
wiley   +1 more source

USP8‐Governed MDA5 Homeostasis Promotes Innate Immunity and Autoimmunity

open access: yesAdvanced Science, EarlyView.
This study reveals that USP8 stabilizes MDA5 via AKT‐mediated phosphorylation (Ser718), enhancing their interaction and MDA5 deubiquitination. USP8 inactivation degrades MDA5, suppressing type I IFN and cytokine production. Pharmacological inhibition of USP8/AKT alleviates MDA5‐driven autoimmunity, demonstrating the USP8‐MDA5 axis as a therapeutic ...
Qimin Zhang   +9 more
wiley   +1 more source

PlantGPT: An Arabidopsis‐Based Intelligent Agent that Answers Questions about Plant Functional Genomics

open access: yesAdvanced Science, EarlyView.
PlantGPT integrates 60 000+ plant research articles with Arabidopsis phenotype‐gene data through retrieval‐augmented generation and fine‐tuning of Llama3‐8B. This open‐source, specialized AI system outperforms general large language models in plant gene‐phenotype relationships, establishing a new paradigm for functional genomics research and molecular ...
Ruixiang Zhang   +14 more
wiley   +1 more source

Home - About - Disclaimer - Privacy