Results 41 to 50 of about 680,154 (292)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
CRISPR-Cas9 gene-editing to assess the role of RF-amide−related peptide 3 in ovine seasonal breeding
AnimalSeasonal breeding is an adaptive strategy that ensures the birth of the offspring during the best time of year and allows energy saving in times of food scarcity and adverse environmental conditions.
C. Richard +16 more
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Fluorinated esters of polycarboxylic acids [PDF]
, 1973 Fluorine containing esters of polycarboxylic acids are discussed.
Breed, L. L., Elliott, R. L.
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Prediction of cull cow carcass characteristics from live weight and body condition score measured pre slaughter [PDF]
, 2009 peer-reviewedA study was conducted to provide information on the degree of carcass finish of Irish cull cows and to investigate the usefulness of live animal measurements for the prediction beef breeds (albeit with a moderate R2 value compared to the ...
Buckley, Frank +5 more
core
Environmental aesthetics, social engagement and aesthetic experiences in Central Asia [PDF]
, 2015 In this essay, I explore the Youth Theatre for Peace (YTP) project in relation to environmental aesthetics and engaged participatory practices towards tolerance building in Central Asia. My main argument is that cultural histories of storytelling, manas (
Breed, Ananda
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
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CRISPR/Cas9-editing of PRNP in Alpine goats
Veterinary ResearchMisfolding of the cellular PrP (PrPc) protein causes prion disease, leading to neurodegenerative disorders in numerous mammalian species, including goats. A lack of PrPc induces complete resistance to prion disease.
Aurélie Allais-Bonnet +19 more
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Journal of the American Mosquito Control Association, 2006 Believing that science is about precision in defining its terms, we propose the use of breeding as an all-encompassing term for mosquito activity does not always represent the reality of what is happening at a site where mosquitoes, in whatever stage, are present.
Henry, Rupp +2 more
openaire +2 more sources
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
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