Results 51 to 60 of about 269,502 (309)

CRISPR/Cas9-editing of PRNP in Alpine goats

Veterinary Research
Misfolding of the cellular PrP (PrPc) protein causes prion disease, leading to neurodegenerative disorders in numerous mammalian species, including goats. A lack of PrPc induces complete resistance to prion disease.
Aurélie Allais-Bonnet, Christophe Richard, Marjolaine André, Valérie Gelin, Marie-Christine Deloche, Aurore Lamadon, Gwendoline Morin, Béatrice Mandon-Pépin, Eugénie Canon, Dominique Thépot, Johann Laubier, Katayoun Moazami-Goudarzi, Ludivine Laffont, Olivier Dubois, Thierry Fassier, Patrice Congar, Olivier Lasserre, Tiphaine Aguirre-Lavin, Jean-Luc Vilotte, Eric Pailhoux   +19 more
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

L’épigénétique et la construction du phénotype chez le bovin

INRAE Productions Animales, 2020
En élevage bovin, une part importante de la variance phénotypique échappe à la sélection génétique, car l’expression des gènes qui contrôlent les caractères d’intérêt est déterminée par des facteurs à la fois génétiques et environnementaux.
Nathalie BEAUJEAN, Marion BOUTINAUD, Ève DEVINOY, Hélène JAMMES, Sandrine LE GUILLOU, Fabienne LE PROVOST, Chistine LEROUX, Lenha MOBUCHON, Maëlle PANNETIER, Eli SELLEM, Hélène KIEFER   +10 more
doaj   +1 more source

Dynamics of cattle sperm sncRNAs during maturation, from testis to ejaculated sperm

Epigenetics & Chromatin, 2021
Background During epididymal transit, spermatozoa go through several functional maturation steps, resulting from interactions with epididymal secretomes specific to each region.
Eli Sellem, Sylvain Marthey, Andrea Rau, Luc Jouneau, Aurelie Bonnet, Chrystelle Le Danvic, Benoît Guyonnet, Hélène Kiefer, Hélène Jammes, Laurent Schibler   +9 more
doaj   +1 more source

The breeding program of Latxa breed [PDF]

Biotechnology in Animal Husbandry, 2007
The present paper describes the breeding program of Latxa breed in Spain. Latxa?s breeding program has been on-going since 1984 and it is focused on increasing milk yield. As a consequence of its implementation, an annual genetic improvement of 3% in milk yield has obtained. Currently, new traits are being considered in the selection breeding goal.
openaire   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Accelerating Onset of Puberty Through Modification of Early Life Nutrition Induces Modest but Persistent Changes in Bull Sperm DNA Methylation Profiles Post-puberty

Frontiers in Genetics, 2020
In humans and model species, alterations of sperm DNA methylation patterns have been reported in cases of spermatogenesis defects, male infertility and exposure to toxins or nutritional challenges, suggesting that a memory of environmental or ...
Jean-Philippe Perrier, David A. Kenny, Aurélie Chaulot-Talmon, Aurélie Chaulot-Talmon, Colin J. Byrne, Colin J. Byrne, Eli Sellem, Luc Jouneau, Luc Jouneau, Anne Aubert-Frambourg, Anne Aubert-Frambourg, Laurent Schibler, Hélène Jammes, Hélène Jammes, Patrick Lonergan, Sean Fair, Hélène Kiefer, Hélène Kiefer   +17 more
doaj   +1 more source

Finding guidelines on social change in the two-tiered narrative and diakonia in the Gospel of John [PDF]

, 2015
It is shown in this article that the Gospel of John describes a battle between darkness and light, life and death, chaos and God’s new order. Although the certainty is given right at the beginning of the Gospel that the darkness will not overcome the ...
Breed, Gert
core   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Breed Street news flashes

, 1942
An issue of a newsletter, "Breed Street news flashes," published by Breed Street Elementary School. "Good-bye to our Japanese" section informs that their Japanese American students are being removed.The Kuwahara Family Papers contains documentation of ...
Breed Street Elementary School
core   +1 more source