Results 51 to 60 of about 1,563,321 (361)

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Cassava Brown Streak Disease Response and Association With Agronomic Traits in Elite Nigerian Cassava Cultivars

Frontiers in Plant Science, 2021
Cassava mosaic geminiviruses (CMGs) and cassava brown streak viruses (CBSVs) cause the highest yield losses in cassava production in Africa. In particular, cassava brown streak disease (CBSD) is and continues to be a significant constraint to optimal ...
Chukwuka Ugochukwu Ano, Chukwuka Ugochukwu Ano, Mildred Ochwo-Ssemakula, Angele Ibanda, Angele Ibanda, Alfred Ozimati, Paul Gibson, Paul Gibson, Joseph Onyeka, Damian Njoku, Chiedozie Egesi, Chiedozie Egesi, Chiedozie Egesi, Robert S. Kawuki   +13 more
doaj   +1 more source

Benefit-cost analysis of participatory breeding program in Syria [PDF]

, 2016
Participatory plant breeding is seen by several scientists as a way to overcome the limitations of conventional breeding by offering farmers the possibility of deciding which varieties better suit their needs and conditions without exposing them to any
Ceccarelli, Salvatore, Grando, Stefania, Mustafa, Yasmin   +2 more
core  

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Utilization of in Vitro Anther Culture in Spelt Wheat Breeding

Plants, 2019
The efficiency of in vitro anther culture was screened in a full diallel population of four spelt wheat genotypes and ten F1 hybrids. Genotype dependency was observed based on the data of embryo-like structures (ELS), green-, albino plantlets.
Csaba Lantos, Szandra Purgel, Katalin Ács, Bernadett Langó, Lajos Bóna, Krisztina Boda, Ferenc Békés, János Pauk   +7 more
doaj   +1 more source

The effect of a strict breeding strategy on overall growth and the prevalence of inherited disorders in the double-muscled Belgian Blue beef breed [PDF]

, 2005
Muscular conformation is the main breeding goal in the double-muscled (I)M) Belgian Blue beef breed (BBB). In recent years the muscularity has improved enormously, though at the same time the growth rate has decreased and the prevalence of a number of ...
Coopman, Frank, Dewulf, Jeroen, Van Zeveren, Alex   +2 more
core  

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

The reproductive dynamics of temperate amphibians: a review [PDF]

, 2007
The annual life cycle of pond breeding amphibians is characterized by periodical migrations between three critical habitats: breeding, post breeding - feeding - and hibernating.
Geltsch, Ioana Cristina, Hartel, Tibor, Pernetta, Angelo, Sas, Istvan   +3 more
core   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

The Effect of Selected Factors on the Growth Ability of Charolais Cattle

Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2014
The aim of this work was to analyze the growth abilities of bull and heifer calves (n = 190) of the Charolais breed calved in one herd from 2006 to 2011.
Renáta Toušová, Jaromír Ducháček, Luděk Stádník, Martin Ptáček, Jan Beran   +4 more
doaj   +1 more source