Results 51 to 60 of about 1,600,675 (344)

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source

Genomic prediction and quantitative trait locus discovery in a cassava training population constructed from multiple breeding stages [PDF]

, 2020
Open Access Article; Published online: 11 Dec 2019Assembly of a training population (TP) is an important component of effective genomic selection‐based breeding programs.
Egesi, C., Jannink, Jean-Luc, Kawuki, R., Kulembeka, H., Lozano, R., Mrema, E., Mtunda, K., Ozimati, A., Rabbi, Ismail Y., Salum, K., Somo, M., Wolfe, M.D.   +11 more
core   +1 more source

Serial amplification of tau filaments using Alzheimer's brain homogenates and C322A or C322S recombinant tau

FEBS Letters, EarlyView.
We investigated the seeded assembly of 0N3R tau and two variants, C322A and C322S, designed to model the mutation landscape at residue 322, using Alzheimer's disease brain homogenates in a real‐time quaking‐induced conversion (RT‐QuIC) assay. The C322A variant formed filaments that partially resembled the paired helical filament (PHF) structure ...
Alessia Santambrogio, Sofia Lövestam, Michael A. Metrick II, Thomas Löhr, Peifeng Xu, Nicholas C. T. Gallagher, Bernardino Ghetti, Byron Caughey, Sjors H. W. Scheres, Michele Vendruscolo   +9 more
wiley   +1 more source

Management of broodstock and quality control of fish seed in Hungary [PDF]

, 2002
Common carp (Cyprinus carpio) breeding has a long tradition in Hungary. However, recent economic changes in Eastern Europe and new developments in aquaculture necessitated the need for ensuring quality of the brood stock used in hatcheries and the legal ...
Bakos, J., Gorda, S., Jeney, Z., Varadi, L.   +3 more
core  

ACSS2 involved in acetyl‐CoA synthesis regulates skeletal muscle function

FEBS Letters, EarlyView.
The enzyme acyl‐coenzyme A synthetase short‐chain family member‐2 (ACSS2) catalyzes the conversion of acetate to acetyl‐CoA, but its function in skeletal muscle is unclear. We studied ACSS2 deficiency in mouse and fly models. Skeletal muscle from the mouse model showed atrophic fibers, excess lipid, and depleted NADH.
Mekala Gunasekaran, Gloriana Campos, Natalya M. Wells, Khanhlinh Lambuu, Isabelle Draper, Christina A. Pacak, Peter B. Kang   +6 more
wiley   +1 more source

ARTICLE - Path analysis of iron and zinc contents and others traits in cowpea [PDF]

Crop Breeding and Applied Biotechnology, 2012
The objective of this study was to estimate the direct and indirect effects of agronomic and culinary traits on iron and zinc contents in 11 cowpea populations.
Jeane de Oliveira Moura, Maurisrael de Moura Rocha, Regina Lúcia Ferreira Gomes, Francisco Rodrigues Freire Filho, Kaesel Jackson Damasceno e Silva, Valdenir Queiroz Ribeiro   +5 more
doaj  

Balancing Breeding for Growth and Fecundity in Radiata Pine (Pinus radiata D. Don) Breeding Programme

Evolutionary Applications, 2021
Tree breeding has focused on increasing stem volume growth with a cost to fecundity. However, fecundity is important in maintaining the fitness in natural stands and facilitating cross‐pollination to advance breeding populations.
Harry X. Wu, Richard Ker, Zhiqiang Chen, Milos Ivkovic   +3 more
doaj   +1 more source

Breeding beyond genomics [PDF]

Journal of Animal Breeding and Genetics, 2021
Peer ...
openaire   +6 more sources

Animal breeding in organic farming [PDF]

, 2001
After a general introduction into the available breeding techniques for animal breeding and an overview of the organic principles, points for discussion are identified and scenario's for organically accepted breeding methods are ...
Baars, T., Groen, A.F., Nauta, W.J., Roep, D., Veerkamp, R.F.   +4 more
core   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source