Results 81 to 90 of about 1,131,323 (347)

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Speed breeding is a powerful tool to accelerate crop research and breeding

Nature Plants, 2018
The growing human population and a changing environment have raised significant concern for global food security, with the current improvement rate of several important crops inadequate to meet future demand1.
Amy Watson, Sreya Ghosh, Matthew J. Williams, W. Cuddy, J. Simmonds, M. Rey, M. Asyraf Md Hatta, A. Hinchliffe, A. Steed, Daniel Reynolds, Nikolai M. Adamski, A. Breakspear, Andrey V Korolev, Tracey Rayner, Laura E. Dixon, A. Riaz, W. Martin, M. Ryan, D. Edwards, J. Batley, H. Raman, J. Carter, C. Rogers, C. Domoney, G. Moore, W. Harwood, P. Nicholson, M. Dieters, I. DeLacy, Ji Zhou, C. Uauy, S. Boden, R. Park, B. Wulff, L. Hickey   +34 more
semanticscholar   +1 more source

Cassava breeding and agronomy in Asia: 50 years of history and future directions

Breeding Science, 2020
In Asia, cassava (Manihot esculenta) is cultivated by more than 8 million farmers, driving the rural economy of many countries. The International Center for Tropical Agriculture (CIAT), in partnership with national agricultural research institutes (NARIs)
A. Malik, P. Kongsil, V. Nguyễn, Wenjun Ou, Sholihin, Pao Srean, M. Sheela, L. A. Becerra López-Lavalle, Yoshinori Utsumi, Cheng Lu, P. Kittipadakul, Hữu Hỷ Nguyễn, H. Ceballos, Trọng Hiển Nguyễn, Michael Selvaraj Gomez, Pornsak Aiemnaka, R. Labarta, Songbi Chen, Suwaluk Amawan, Sophearith Sok, Laothao Youabee, M. Seki, H. Tokunaga, Wenquan Wang, Kaimian Li, Hai Anh Nguyen, Văn Đồng Nguyễn, L. Hàm, M. Ishitani   +28 more
semanticscholar   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Características vegetativas e seus efeitos sobre a produção de bananeira em três ciclos Vegetative traits and your effects on production of banana evaluated in three cycles

Revista Brasileira de Fruticultura, 2012
A produtividade em bananeira é um caráter complexo que resulta da associação de diferentes fatores, influenciados pelo ambiente. Este trabalho teve por objetivo estudar os efeitos diretos e indiretos de características vegetativas sobre a produção de ...
Lauro Saraiva Lessa, Tadário Kamel de Oliveira, Edson Perito Amorim, Giselle Mariano Lessa de Assis, Sebastião de Oliveira e Silva   +4 more
doaj  

Molecular mapping and validation of quantitative trait loci for content of micronutrients in wheat grain

Frontiers in Plant Science
Manganese (Mn), iron (Fe), copper (Cu), zinc (Zn), and selenium (Se) are essential micronutrients for human health. However, the genetic basis for the content of Mn, Fe, Cu, Zn, and Se in wheat grains remains unclear.
Xiangdong Chen, Junchao You, Nannan Dong, Di Wu, Die Zhao, Rui Yong, Wenjing Hu   +6 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

On the Road to Breeding 4.0: Unraveling the Good, the Bad, and the Boring of Crop Quantitative Genomics.

Annual Review of Genetics, 2018
Understanding the quantitative genetics of crops has been and will continue to be central to maintaining and improving global food security. We outline four stages that plant breeding either has already achieved or will probably soon achieve.
Jason G. Wallace, Eli Rodgers-Melnick, E. Buckler   +2 more
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source