Results 41 to 50 of about 2,339 (265)

The Design of Water Loop Facility for Supporting the WCLL Breeding Blanket Technology and Safety

Energies, 2023
The WCLL Breeding Blanket of DEMO and the Test Blanket Module (TBM) of ITER require accurate R&D activities, i.e., concept validation at a relevant scale and safety demonstrations. In view of this, the strategic objective of the Water Loop (WL) facility,
Alessandra Vannoni, Pietro Arena, Bruno Gonfiotti, Marica Eboli, Pierdomenico Lorusso, Amelia Tincani, Nicolò Badodi, Antonio Cammi, Fabio Giannetti, Cristiano Ciurluini, Nicola Forgione, Francesco Galleni, Ilenia Catanzaro, Eugenio Vallone, Pietro Alessandro Di Maio, Pietro Agostini, Alessandro Del Nevo   +16 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

HCCR breeding blankets optimization by changing neutronic constrictions

Nuclear Engineering and Technology, 2021
The neutronic analysis of Helium Cooled Ceramic Reflector (HCCR) breeding blankets has been performed using the 3D Monte Carlo code MCNPX and ENDF nuclear data library. This study aims to reduce 6Li percentage in the breeder zones as much as possible ensuring tritium self-sufficiency.
R. Zadfathollah Seighalani, M. Sedaghatizade, H. Sadeghi   +2 more
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The effect of Li2TiO3 pebbles on the mechanical properties of ARAA under breeding blanket conditions

Nuclear Materials and Energy
The breeding blanket serves as a critical element for achieving a self-sustaining tritium cycle and generating sufficient energy in fusion reactors.
Yunsong Jung, Youngah Park, Duck Young Ku, Yi-Hyun Park, Hyoseong Gwon   +4 more
doaj   +1 more source

The DEMO Water-Cooled Lead–Lithium Breeding Blanket: Design Status at the End of the Pre-Conceptual Design Phase

Applied Sciences, 2021
The Water-Cooled Lead–Lithium Breeding Blanket (WCLL BB) is one of the two blanket concept candidates to become the driver blanket of the EU-DEMO reactor. The design was enacted with a holistic approach. The influence that neutronics, thermal-hydraulics (
Pietro Arena, Alessandro Del Nevo, Fabio Moro, Simone Noce, Rocco Mozzillo, Vito Imbriani, Fabio Giannetti, Francesco Edemetti, Antonio Froio, Laura Savoldi, Simone Siriano, Alessandro Tassone, Fernando Roca Urgorri, Pietro Alessandro Di Maio, Ilenia Catanzaro, Gaetano Bongiovì   +15 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source