Results 71 to 80 of about 478,542 (302)

Neutronics experiment of tritium breeding in supercritical CO2 cooled lithium-lead blanket mock-up by D–T neutron irradiation

Nuclear Fusion
The tritium breeding capacity of fusion blankets is a critical factor in achieving tritium self-sufficiency in fusion reactors. Current designs for tritium production in blankets are based on neutronics simulations, whose accuracy requires experimental ...
Qiankun Shao, Qingjun Zhu, Zuocong Liu, Tianyi Liu, Jie Bao, Songlin Liu   +5 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Turning the heat up on independent culling in crop breeding

, 2022
Most grain crops are sensitive to heat stress during anthesis which causes substantial reductions in grain yield, and heat stress tolerance (HST) is therefore an important trait for selection in crop breeding programmes during the 21st century.
Li, Li, Cowling, Wallace
core  

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

ITER Water Cooled Lithium Lead Test Blanket System transient thermal-hydraulic analysis

Nuclear Fusion
The planned experimental activities of the ITER Test Blanket Module (TBM) program will be a key step in understanding the physics and technologies required for tritium breeding blankets, which are essential for achieving tritium self-sufficiency in a ...
Tommaso Glingler, Gianfranco Caruso, Danilo Nicola Dongiovanni, Salvatore D’Amico, Italo Ricapito, Paul Wouters, Francesca Fantini, Joelle Elbez-Uzan, Sandrine Rosanvallon, Matteo D’Onorio   +9 more
doaj   +1 more source

Conceptual radiation shielding design of the integrated breeding test facility at KFE

Nuclear Engineering and Technology
The Integrated Breeding Test Facility (IBTF) is being developed by Korea Institute of Fusion Energy to assess the long-term performance of breeding blankets under continuous irradiation environment.
Hyoseong Gwon, Dohyun Kim, Seonghee Hong, Mu-Young Ahn   +3 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Searching for exotic scalars at fusion reactors

Journal of High Energy Physics
Part of the energy created in deuterium-tritium fusion reactors is carried away from plasma by a high-intensity neutron flux, which is then absorbed by the reactor’s inner walls.
Chaja Baruch, Patrick J. Fitzpatrick, Tony Menzo, Yotam Soreq, Sokratis Trifinopoulos, Jure Zupan   +5 more
doaj   +1 more source

Tritium Extraction from Liquid Blankets of Fusion Reactors via Membrane Gas–Liquid Contactors

Journal of Nuclear Engineering
The exploitation of fusion energy in tokamak reactors relies on efficient and reliable tritium management. The tritium needed to sustain the deuterium–tritium fusion reaction is produced in the Li-based blanket surrounding the plasma chamber, and ...
Silvano Tosti, Luca Farina
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source