Results 51 to 60 of about 1,329 (294)

Conceptual design of solid-type Pb x Li y eutectic alloy breeding blanket for CFETR

Nuclear Fusion, 2023
As a key component of the Chinese Fusion Engineering and Test Reactor (CFETR), the blanket is responsible for tritium breeding, neutron shielding and energy conversion.
K. Jiang, Q. Wu, L. Chen, S. Liu
doaj   +1 more source

Effect of reactor size on the breeding economics of LMFBR blankets

, 1975
The effect of reactor size on the neutronic and economic performance of LMFBR blankets driven by radially-power-flattened cores has been investigated using both simple models and state-of-the-art computer methods.
Tagishi, A., Driscoll, M. J.
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Avian Cholera emergence in Arctic-nesting northern Common Eiders: using community-based, participatory surveillance to delineate disease outbreak patterns and predict transmission risk

Ecology and Society, 2016
Emerging infectious diseases are a growing concern in wildlife conservation. Documenting outbreak patterns and determining the ecological drivers of transmission risk are fundamental to predicting disease spread and assessing potential impacts on ...
Samuel A. Iverson, Mark R. Forbes, Manon Simard, Catherine Soos, H. Grant Gilchrist   +4 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Inverse Kinematics and Statics-Based Motion Planning of a 7-DoF Transporter for DEMO-Type Breeding Blankets

Machines
Future fusion power plants like DEMO must be remotely maintained for safety, including breeding blankets (BBs) weighing up to 180 t. The BB vertical transporter (BBVT), a crane-like redundant robot with 7 joints, has been previously designed for handling
Hjalte Durocher, Christian Bachmann, Rocco Mozzillo, Günter Janeschitz, Xuping Zhang   +4 more
doaj   +1 more source

Tritium Breeding in Fusion Reactors [PDF]

, 1982
Key technological problems that influence tritium breeding in fusion blankets are reviewed. The breeding potential of candidate materials is evaluated and compared to the tritium breeding requirements.
Abdou, M. A.
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Two Fusion Reactor Blankets with Vanadium as Structural Material

, 1974
Calculations of the tritium breeding ratio and heating rates for two proposed blanket designs are obtained by using the Monte Carlo method. The materials used for the blanket are vanadium and lithium. Lithium is used to slow down the neutrons and produce
James E. Struve, Nick Tsoulfanidis, Struve, J. E., Tsoulfanidis, Nicholas   +3 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source