A minimal cellulosome‐like system in Cellulosilyticum lentocellum
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan +2 more
wiley +1 more source
Mathematical Modeling and Software Tools for Breeding Value Estimation Based on Phenotypic, Pedigree and Genomic Information of Holstein Friesian Cattle in Serbia. [PDF]
Štrbac L +7 more
europepmc +1 more source
BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley +1 more source
ssGBLUP Method Improves the Accuracy of Breeding Value Prediction in Huacaya Alpaca. [PDF]
Mancisidor B +6 more
europepmc +1 more source
Evaluation of breeding values of sires and cows in dairy breeds [PDF]
V. O. Danshin +2 more
openaire +1 more source
CGIAR Excellence in Breeding Platform - Plan of Work and Budget 2018
CGIAR Excellence in Breeding Platform - Plan of Work and Budget for ...
CGIAR Excellence in Breeding Platform
core
MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima +8 more
wiley +1 more source
Quality of breeding value predictions from longitudinal analyses, with application to residual feed intake in pigs. [PDF]
David I +4 more
europepmc +1 more source
IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source

