Results 81 to 90 of about 268,924 (264)
Implementation of SCC breeding values in Italian Jersey breed
, 2021 In the framework of the LATTeco project, ANAFIJ (Associazione Nazionale Allevatori della Razza Frisona e Jersey Italiana) has been working on improving animal welfare, biodiversity and sustainability. Focusing on animal welfare, ANAFIJ has implemented a genetic evaluation for somatic cell count (SCC) in the Italian Jersey population.
Anna Fabris, Mauro Penasa, Tania Bobbo
openaire +1 more source
World Rabbit Science, 2018 The effects of mitogenome variation on economically important traits have been reported in a number of domestic animal species. In this study, the first of its kind on rabbits, we have performed the estimation of the contribution of cytoplasmic and D ...
Nguyen Thao Nguyen +7 more
doaj +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Trends in Breeding Value and Production
Journal of Dairy Science, 1977 Over 3.6 million first lactation records by cows on official test were studied. About 15.5 yr of data for six dairy breeds were represented. Sire breeding value was twice the sire's Modified Contemporary Deviation from the USDA Sire Summary. Sire breeding values for milk and fat of cows calving in the later years increased for all breeds but Ayrshires,
R.L. Powell, H.D. Norman, F.N. Dickinson
openaire +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells
FEBS Open Bio, EarlyView.RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour +2 more
wiley +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
IMPLEMENTATION OF GENOME-WIDE SELECTION IN WHEAT
Вавиловский журнал генетики и селекции, 2014 With the expected development of thousands of molecular markers in most crops, the marker-assisted selection theory has recently shifted from the use of a few markers targeted in QTL regions (or derived from candidate or validated genes) to the use of ...
G. Charmet, E. Storlie
doaj
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
FEBS Open Bio, EarlyView.The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source