Results 61 to 70 of about 289,219 (311)

Marker-assisted breeding value estimation for mastitis resistance in Finnish Ayrshire cattle

, 2010
Marker-assisted breeding value estimation is expected to increase the accuracy of estimated breeding values, especially for traits with low heritability.
Lidauer, M., Mulder, H. A., J.H. Vilkki, Strandén, Ismo, R.F. Veerkamp, Strandén, I., Vilkki, Johanna H., H.A. Mulder, Veerkamp, R.F., Lidauer, Martin H., Mulder, H.A., Veerkamp, R. F., I. Strandén, Vilkki, J.H., M.H. Lidauer   +14 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Variation and Selection of Growth and Wood Property Traits in Cunninghamia lanceolata Full-sib Families

Guangdong nongye kexue
【Objective】The study aims to prepare new and excellent Cunninghamia lanceolata (Lamb.) Hook germplasm materials and select superior families of C. lanceolata families, thus promoting the breeding process of higher generations of the species.【Method】Ten ...
Rong HUANG, Runhui WANG, Su YAN, Ruping WEI, Guangdi WU, Huiquan ZHENG   +5 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Parâmetros genéticos e tendências genética e fenotípica para características de crescimento em uma população da raça Brangus Genetic parameters and genetic and phenotypic trends for growing traits for a Brangus breed population

Revista Brasileira de Zootecnia, 2009
Para estimar parâmetros genéticos e a tendência genética e fenotípica para peso à desmama (PD), peso ao sobreano (PS), ganho médio diário do nascimento à desmama (GMDND), ganho médio diário da desmama ao sobreano (GMDDS), dias para atingir 160 kg na fase
Jader Silva Lopes, Paulo Roberto Nogara Rorato, Tomás Weber, Mariana de Almeida Dornelles, Juliana Grigoletto Comin, Ronyere Olegário de Araújo   +5 more
doaj   +1 more source

The effect of genomic information on optimal contribution selection in livestock breeding programs

, 2013
Long-term benefits in animal breeding programs require that increases in genetic merit be balanced with the need to maintain diversity (lost due to inbreeding). This can be achieved by using optimal contribution selection.
Hickey, John M, Clark, Samuel A, John M Hickey, Brian P Kinghorn, van der Werf, Julius Hj, Samuel A Clark, Julius HJ van der Werf, Kinghorn, Brian P   +7 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

A plea to implement robustness into a breeding goal: poultry as an example

, 2008
The combination of breeding for increased production and the intensification of housing conditions have resulted in increased occurrence of behavioral, physiological, and immunological disorders.
Brom, F.W.A., L. Star, E. D. Ellen, F. W. A. Brom, Uitdehaag, K.A., Star, L., Ellen, E.D., K. Uitdehaag   +7 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Genomic breeding value prediction: methods and procedures

Animal, 2010
Animal breeding faces one of the most significant changes of the past decades - the implementation of genomic selection. Genomic selection uses dense marker maps to predict the breeding value of animals with reported accuracies that are up to 0.31 higher than those of pedigree indexes, without the need to phenotype the animals themselves, or close ...
openaire   +4 more sources