Results 111 to 120 of about 289,219 (311)

Sensitivity of methods for estimating breeding values using genetic markers to the number of QTL and distribution of QTL variance

, 2010
The objective of this simulation study was to compare the effect of the number of QTL and distribution of QTL variance on the accuracy of breeding values estimated with genomewide markers (MEBV).
Bovenhuis, H., Bastiaansen John WM, Bovenhuis Henk, van Arendonk Johan AM, Calus Mario PL, John W. M. Bastiaansen, Mario P. L. Calus, Coster, A., Albart Coster, Henk Bovenhuis, Bastiaansen, J.W.M., Calus, M.P.L., Johan A. M. van Arendonk, Arendonk, J.A.M., van, van Arendonk, J.A.M., Coster Albart   +15 more
core   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

Improving Breeding Value Reliability with Genomic Data in Breeding Groups of Charolais. [PDF]

Genes (Basel), 2023
Brzáková M, Veselá Z, Vařeka J, Bauer J.   +3 more
europepmc   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Modelling Agricultural Systems: Applications to Livestock Breeding

Traditionally the evaluation of animal genetic traits has focused primarily on production traits and the construction of selection indices. Selection indices, however, fail to consider the effect of management practices and the environment on ...
Hattam, Caroline
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Implementation of different relationship estimate methodologies in breeding value prediction in kiwiberry (Actinidia arguta). [PDF]

Mol Breed, 2023
Mertten D, Baldwin S, Cheng CH, McCallum J, Thomson S, Ashton DT, McKenzie CM, Lenhard M, Datson PM.   +8 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Exploring the genetic resources of yam in the Democratic Republic of Congo: implications for breeding

Frontiers in Horticulture
IntroductionLandrace accession of yam species in the Democratic Republic of Congo (DRC) represents a valuable genetic resource for yam breeding programs. These accessions possess traits such as stress resilience and desirable food quality attributes that
Idris Adejumobi, Idris Adejumobi, Adeyinka Saburi Adewumi, Fatim Ouattara, Esther Olatunde, Joseph Adheka, Didy Onautshu, Siraj Ismail Kayondo, Oluwafemi Alaba, Hapson Mushoriwa, Paterne Angelot Agre   +10 more
doaj   +1 more source

Breeding for trypanotolerance in African cattle

, 2001
Trypanosomosis, or sleeping sickness, is one of the most important livestock diseases in Africa. Some West African cattle breeds show a degree of resistance to a trypanosome infection: they are trypanotolerant.
van der Waaij, E.H., Waaij, E.H., van der   +1 more
core