Results 51 to 60 of about 1,097,437 (198)

Randomized controlled trial examining the adjunctive use of nicotine lozenges with MyLastDip: An eHealth smokeless tobacco cessation intervention

open access: yesInternet Interventions, 2015
Introduction: Promising Web-based interventions for smokeless tobacco cessation have emerged. We describe a randomized controlled trial (RCT) testing the relative benefits of adding the nicotine lozenge as an adjunct to the MyLastDip Web-based smokeless ...
Brian G. Danaher   +7 more
doaj   +1 more source

Research Priorities for Robust Climate Assessments in the United States

open access: yesEarth's Future, Volume 14, Issue 9, September 2026.
Abstract Scientific assessments play a critical role in synthesizing evidence to support evidence‐based decision‐making in many sectors and topics. For climate change, large‐scale assessments like the Intergovernmental Panel on Climate Change (IPCC) and the United States (U.S.) National Climate Assessment (NCA) reports help many different users—from ...
Melissa A. Kenney   +174 more
wiley   +1 more source

Glycans Related to the CA19-9 Antigen Are Increased in Distinct Subsets of Pancreatic Cancers and Improve Diagnostic Accuracy Over CA19-9Summary

open access: yesCellular and Molecular Gastroenterology and Hepatology, 2016
Background & Aims: The cancer antigen 19-9 (CA19-9) is the current best biomarker for pancreatic cancer, but it is not increased in approximately 25% of pancreatic cancer patients at a cut-off value that provides a 25% false-positive rate.
Huiyuan Tang   +8 more
doaj   +1 more source

Prediagnostic serum biomarkers as early detection tools for pancreatic cancer in a large prospective cohort study. [PDF]

open access: yesPLoS ONE, 2014
The clinical management of pancreatic cancer is severely hampered by the absence of effective screening tools.Sixty-seven biomarkers were evaluated in prediagnostic sera obtained from cases of pancreatic cancer enrolled in the Prostate, Lung, Colorectal,
Brian M Nolen   +9 more
doaj   +1 more source

SMAD4 loss is associated with response to neoadjuvant chemotherapy plus hydroxychloroquine in patients with pancreatic adenocarcinoma

open access: yesClinical and Translational Science, 2021
SMAD4, a tumor suppressor gene, is lost in up to 60%–90% of pancreatic adenocarcinomas (PDAs). Loss of SMAD4 allows tumor progression by upregulating autophagy, a cell survival mechanism that counteracts apoptosis and allows intracellular recycling of ...
Naomi Fei   +9 more
doaj   +1 more source

Molecular Ontology Predicts Output Connections From the Nucleus of the Solitary Tract

open access: yesJournal of Comparative Neurology, Volume 534, Issue 8, August 2026.
The nucleus of the solitary tract (NTS) integrates visceral inputs to coordinate appetite and digestion, breathing, and cardiorespiratory reflexes. Using cell‐type‐specific tracing, we show that excitatory Lmx1b neurons project broadly to brainstem and forebrain targets, whereas inhibitory output remains largely brainstem‐restricted. Catecholaminergic (
Silvia Gasparini   +5 more
wiley   +1 more source

NMR structure of Hsp12, a protein induced by and required for dietary restriction-induced lifespan extension in yeast. [PDF]

open access: yesPLoS ONE, 2012
Dietary restriction (DR) extends lifespan in yeast, worms, flies and mammals, suggesting that it may act via conserved processes. However, the downstream mechanisms by which DR increases lifespan remain unclear.
Andrew P Herbert   +9 more
doaj   +1 more source

Patient‐reported outcomes, postoperative pain and pain relief after day‐case surgery (POPPY): short‐term peri‐operative analgesic use

open access: yesAnaesthesia, Volume 81, Issue 8, Page 1057-1067, August 2026.
Summary Introduction An increasing proportion of complex surgical procedures are being performed in the UK as day‐cases, with variable and limited follow up. Discharge prescriptions must provide adequate analgesia, while considering the safety of the patient and public, following best practice guidance and good opioid stewardship.
Anna Ratcliffe   +2083 more
wiley   +1 more source

2'-O methylation of the viral mRNA cap by West Nile virus evades ifit1-dependent and -independent mechanisms of host restriction in vivo. [PDF]

open access: yesPLoS Pathogens, 2012
Prior studies have shown that 2'-O methyltransferase activity of flaviviruses, coronaviruses, and poxviruses promotes viral evasion of Ifit1, an interferon-stimulated innate immune effector protein.
Kristy J Szretter   +9 more
doaj   +1 more source

Resisting Psychopathologies of Dominance and Authoritarianism: From Trumpian Dystopia to Better Tomorrows

open access: yesJournal of Psychiatric and Mental Health Nursing, Volume 33, Issue 4, Page 618-625, August 2026.
ABSTRACT Background The world and mental health nursing face several crises that, in different ways, reflect problems of dominance. Global politics are afflicted with a growth of support for right‐wing ideologies associated with domineering authoritarian leaders.
Michael Haslam, Mick McKeown
wiley   +1 more source

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