Results 31 to 40 of about 6,328 (209)

Gene editing enables rapid engineering of complex antibiotic assembly lines

Nature Communications, 2021
Engineering biosynthetic assembly lines is a powerful path to new natural products but is challenging with current methods. Here the authors use CRISPR-Cas9 to exchange subdomains within NRPS to alter substrate selectivity.
Wei Li Thong, Yingxin Zhang, Ying Zhuo, Katherine J. Robins, Joanna K. Fyans, Abigail J. Herbert, Brian J. C. Law, Jason Micklefield   +7 more
doaj   +1 more source

Identification of candidate B-lymphoma genes by cross-species gene expression profiling. [PDF]

PLoS ONE, 2013
Comparative genome-wide expression profiling of malignant tumor counterparts across the human-mouse species barrier has a successful track record as a gene discovery tool in liver, breast, lung, prostate and other cancers, but has been largely neglected ...
Van S Tompkins, Seong-Su Han, Alicia Olivier, Sergei Syrbu, Thomas Bair, Anna Button, Laura Jacobus, Zebin Wang, Samuel Lifton, Pradip Raychaudhuri, Herbert C Morse, George Weiner, Brian Link, Brian J Smith, Siegfried Janz   +14 more
doaj   +1 more source

Availability of Cancer Screening Across HIV Treatment Sites in the IeDEA Consortium

International Journal of Cancer, EarlyView.
In recent years, incorporating comprehensive cancer screening strategies into routine HIV care has gained growing attention. This survey of 220 sites providing HIV care across 41 countries shows that cervical cancer screening has increased in availability over time.
Rachael A. Pellegrino, Bryan E. Shepherd, Sanjay Pujari, Valeria Fink, Gad Murenzi, Miriam Nakalembe, Sally B. Coburn, Eliane Rohner, Antoine Jaquet, Caroline Lade, Brenda Crabtree Ramirez, Kathryn Anastos, Aggrey Semeere, Lesley S. Park, Limpho Mokone, Simon Boni, I Ketut Agus Somia, Emilia M. Jalil, Adebola Adedimeji, Omenge Orang'o, Michael J. Silverberg, Kumbirai Pise Quarter, Eugène Messou, Jeremy Ross, Eduardo Gotuzzo, Patricia Lelo, Helen Byakwaga, Oliver Ezechi, Jonathan Euvrard, Fernanda Maruri, Chad J. Achenbach, Jessica L. Castilho, on behalf of International epidemiology Databases to Evaluate AIDS (IeDEA)   +32 more
wiley   +1 more source

Here Comes the Bride. A Long Overdue Queer Reading of Re-Animator and Bride of Re-Animator

Wielogłos
The paper proposes a queer reading of two movies, Stuart Gordon’s Re-Animator and its sequel Bride of Re-Animator by Brian Yuzna. It examines the relationship between the main characters, Herbert West
Agnieszka Urbańczyk
doaj   +1 more source

φX216, a P2-like bacteriophage with broad Burkholderia pseudomallei and B. mallei strain infectivity

BMC Microbiology, 2012
Background Burkholderia pseudomallei and B. mallei are closely related Category B Select Agents of bioterrorism and the causative agents of the diseases melioidosis and glanders, respectively.
Kvitko Brian H, Cox Christopher R, DeShazer David, Johnson Shannon L, Voorhees Kent J, Schweizer Herbert P   +5 more
doaj   +1 more source

Public Inquiries and UK Press Regulation: A Case of ‘Fading into Forgetfulness’?

The Political Quarterly, EarlyView.
Abstract Why were the proposals for reform of UK press regulation made by Lord Leveson in 2012 not implemented in full, despite popular and parliamentary support for the report's recommendations, and despite the creation of the legal framework for the reformed system of regulation?
John Street, Michael Harker, Samuel Cross   +2 more
wiley   +1 more source

Enhanced Neutrophil Extracellular Trap Formation in Acute Pancreatitis Contributes to Disease Severity and Is Reduced by Chloroquine

Frontiers in Immunology, 2019
Background: Neutrophil extracellular traps (NETs) are generated when activated neutrophils, driven by PAD4, release their DNA, histones, HMGB1, and other intracellular granule components.
Pranav Murthy, Aatur D. Singhi, Mark A. Ross, Patricia Loughran, Pedram Paragomi, Georgios I. Papachristou, David C. Whitcomb, Amer H. Zureikat, Michael T. Lotze, Herbert J. Zeh III, Herbert J. Zeh III, Brian A. Boone, Brian A. Boone   +12 more
doaj   +1 more source

The State Itself as a Vulnerable Subject? Existential Resilience under International Law

The Modern Law Review, EarlyView.
This paper proposes a new framework for analysis of the law governing State continuity, with particular reference to Small Island Developing States (SIDS) threatened with legal extinction as a result of rising sea‐levels. Prevailing wisdom suggests that if States were to lose their inhabitable land or permanently resident populations, their status ...
Alex Green (文浩航)
wiley   +1 more source

‘Fine Men from Afar’: Cricket and Empire on the Home Front

History, EarlyView.
Abstract During the Second World War, contrary to enduring images of bombardment and scarcity, people on Britain's ‘Home Front’ continued to take part in a broad array of sporting activities. Cricket played a more significant role in the wartime sporting landscape than many historians have previously recognized.
Michael Collins
wiley   +1 more source

Enhanced discrimination of malignant from benign pancreatic disease by measuring the CA 19-9 antigen on specific protein carriers. [PDF]

PLoS ONE, 2011
The CA 19-9 assay detects a carbohydrate antigen on multiple protein carriers, some of which may be preferential carriers of the antigen in cancer. We tested the hypothesis that the measurement of the CA 19-9 antigen on individual proteins could improve ...
Tingting Yue, Kevin A Maupin, Brian Fallon, Lin Li, Katie Partyka, Michelle A Anderson, Dean E Brenner, Karen Kaul, Herbert Zeh, A James Moser, Diane M Simeone, Ziding Feng, Randall E Brand, Brian B Haab   +13 more
doaj   +1 more source