Marine diterpenoid targets STING palmitoylation in mammalian cells [PDF]
Communications Chemistry, 2023 Natural products are important sources of therapeutic agents and useful drug discovery tools. The fused macrocycles and multiple stereocenters of briarane-type diterpenoids pose a major challenge to total synthesis and efforts to characterize their ...
Wan-Chi Hsiao +9 more
doaj +2 more sources
A concise synthetic route to the stereotetrad core of the briarane diterpenoids. [PDF]
Org Lett, 2015 A concise synthesis (under 10 steps) of the stereotetrad core of the briarane diterpenoids is reported. This approach harnesses the unique reactivity of salicylate ester derived 2,5-cyclohexadienones to quickly build complexity. In particular, a highly diastereoselective acetylide conjugate addition/β-ketoester alkylation sequence was used to set the ...
Moon NG, Harned AM.
europepmc +6 more sources
Briarenols Q–T: Briaranes from A Cultured Octocoral Briareum stechei (Kükenthal, 1908) [PDF]
Marine Drugs, 2020 Our continuous chemical study of a cultured octocoral Briareum stechei led to the isolation of four new briarane diterpenoids, briarenols Q–T (1–4). The structures of new metabolites 1–4 were established by spectroscopic methods, and compounds 3 and 4 ...
Yi-Lin Zhang +9 more
doaj +2 more sources
Briarenolides F and G, New Briarane Diterpenoids from a <em>Briareum</em> sp. Octocoral [PDF]
Marine Drugs, 2012 Two new briarane diterpenoids, briarenolides, F (<strong>1</strong>) and G (<strong>2</strong>), were isolated from an octocoral identified as <em>Briareum</em> sp.
Jyh-Horng Sheu +11 more
doaj +2 more sources
Briarane-type diterpenoids from the Vietnamese gorgonian Junceella fragilis [PDF]
Natural Product Research, 2019 Ten briarane-type diterpenoids (1–10), including one new stereoisomer 17-epi-junceellolide B (1), were isolated from the MeOH extract of the Vietnamese gorgonian Junceella fragilis. Their structures were elucidated by spectroscopic experiments including 1D and 2D NMR, and HR-QTOF-MS.
Ngoc, Ninh Thi +7 more
openaire +3 more sources
Fragilides K and L, New Briaranes from the Gorgonian Coral Junceella fragilis [PDF]
Molecules, 2018 Two new briarane metabolites—fragilides K (1) and L (2)—along with five known analogues—gemmacolide X, praelolide, juncins P and ZI, and gemmacolide V (3–7)—were extracted and purified from Junceella fragilis, a gorgonian ...
Li-Guo Zheng +5 more
doaj +2 more sources
Terpenoids from Octocorals of the Genus Pachyclavularia [PDF]
Marine Drugs, 2017 In this paper, we reviewed natural compounds isolated from octocorals belonging to the genus Pachyclavularia, including 20 cembrane-, 39 briarane-, and eight briarellin-related diterpenoids, and one secosterol.
Yu-Chia Chang +3 more
doaj +2 more sources
New 8-Hydroxybriaranes from the Gorgonian Coral Junceella fragilis (Ellisellidae) [PDF]
Marine Drugs, 2019 Three new 8-hydroxybriaranes—fragilides R−T (1−3) were obtained from a sea whip gorgonian coral Junceella fragilis. The structures of briaranes 1−3 were elucidated by using spectroscopic methods, including 1D (1H and 13C NMR), 2D (
You-Ying Chen +13 more
doaj +2 more sources
New 11,20-Epoxybriaranes from the Gorgonian Coral Junceella fragilis (Ellisellidae) [PDF]
Molecules, 2019 Two new 11,20-epoxybriaranes, fragilides P (1) and Q (2), as well as two known analogues, robustolide F (3) and juncin Z (4), were obtained from the gorgonian coral Junceella fragilis.
Chia-Cheng Lin +7 more
doaj +2 more sources
Briarenols C–E, New Polyoxygenated Briaranes from the Octocoral Briareum excavatum [PDF]
Molecules, 2017 Three new polyoxygenated briarane diterpenoids, briarenols C–E (1–3), were isolated from the octocoral Briareum excavatum. The structures of briaranes 1–3 were elucidated by interpretation of spectroscopic data, and the methylenecyclohexane ring in 1 was
Nan-Fu Chen +7 more
doaj +2 more sources