Results 21 to 30 of about 80,662 (350)

Tie2 activity in cancer associated myofibroblasts serves as novel target against reprogramming of cancer cells to embryonic-like cell state and associated poor prognosis in oral carcinoma patients

Journal of Experimental & Clinical Cancer Research
Background Myofibroblastic cancer-associated fibroblasts (CAF) in tumor stroma serves as an independent poor prognostic indicator, supporting higher stemness in oral cancer; however, the underlying biology is not fully comprehended.
Paromita Mitra, Uday Saha, Kingsly Joshua Stephen, Priyanka Prasad, Subhashree Jena, Ankit Kumar Patel, Harshavardhan BV, Santosh Kumar Mondal, Sillarine Kurkalang, Sumitava Roy, Arnab Ghosh, Shantanu Saha Roy, Jayasri Das Sarma, Nidhan Kumar Biswas, Moulinath Acharya, Rajeev Sharan, Pattatheyil Arun, Mohit Kumar Jolly, Arindam Maitra, Sandeep Singh   +19 more
doaj   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Associations of Rheumatoid Arthritis Disease Activity with Frailty Over Five Years of Follow‐up

Arthritis Care &Research, Accepted Article.
Objective To evaluate whether rheumatoid arthritis (RA) disease activity is associated with frailty both in cross‐section and longitudinally. Methods Participants within the Veterans Affairs Rheumatoid Arthritis registry enrolled from 2003 to 2022 were included. The exposure was RA disease activity measured by Disease Activity Score in 28‐joints (DAS28)
Courtney N. Loecker, Yangyuna Yang, Punyasha Roul, Aaron Baraff, Myra S. Schmaderer, Lani Zimmerman, Kaleb Michaud, Namrata Singh, Grant W. Cannon, Gary Kunkel, Ted R. Mikuls, Ariela R. Orkaby, Joshua F. Baker, Bryant R. England, Katherine D. Wysham   +14 more
wiley   +1 more source

Probing Intrinsic Charm with Semileptonic B Decays [PDF]

, 2002
We discuss semileptonic B decays of the form B -> J/Psi e nu X as possible probes of intrinsic charm. We calculate the leading order perturbative contribution to the process B- -> J/Psi e- nu_e X and find it to be unobservably small, with a branching ...
A. A. Petrov, B. W. Harris, C. Bernard, C. W. Bernard, C.-H. V. Chang, D. E. Groom, E. Braaten, F. Gabbiani, F. Maltoni, G. Eilam, G. T. Bodwin, G. T. Bodwin, G. Valencia, H. Fritzsch, J.-W. Qiu, Jianwei Qiu, M. Beneke, M. Glück, R. Vogt, R. Vogt, S. J. Brodsky, S. J. Brodsky, S. J. Brodsky, S. J. Brodsky   +23 more
core   +4 more sources

Structure Formation in Butterfly Scales: Interplay of Genetic Control, Mechanical Instabilities, and Dynamic Material Properties

Advanced Functional Materials, EarlyView.
Butterfly wing scales are intricate cuticular functional nanosctructures. This perspective suggests that spatially varying material properties, cytoskeletal constraints, and growth‐driven mechanical instabilities shape the resulting nanoscale architectures created from single cells.
Anupama Prakash, Victoria Lloyd, Yi Yang, Anna‐Lee Jessop, Anthony McDougal, Primož Pirih, Guillaume Duclos, Andrew Parnell, Mathias Kolle, Nicola J. Nadeau, Bodo D. Wilts   +10 more
wiley   +1 more source

Benign Recurrent Intrahepatic Cholestases [PDF]

, 2001
Benign recurrent intrahepatic cholestasis (BRIC) or idiopathic recurrent intrahepatic cholestasis is a rare case. It is a familial and autosomal recessive. The etiology of BRIC is still unknown. We report the case of a patient with BRIC who suffered from
Akbar, F. N. (Femmy), Budihusodo, U. (Unggul), Lesmana, L. A. (L), Marwoto, W. (Wirasmi), Noer, S. (Sjaifoellah)   +4 more
core   +1 more source

Machine Learning for Green Solvents: Assessment, Selection and Substitution

Advanced Science, EarlyView.
Environmental regulations have intensified demand for green solvents, but discovery is limited by Solvent Selection Guides (SSGs) that quantify solvent sustainability. Training a machine learning model on GlaxoSmithKline SSG, a database of sustainability metrics for 10,189 solvents, GreenSolventDB is developed. Integrated with Hansen solubility metrics,
Rohan Datta, Janhavi Nistane, Abhishek Sose, Harikrishna Sahu, Rampi Ramprasad   +4 more
wiley   +1 more source

Indigenous medicinal plant knowledge among the Meitei community of Salungpham village, Thoubal district, Manipur, India

Trees, Forests and People
Indigenous knowledge of medicinal plants represents a vital resource for healthcare, cultural preservation, and scientific exploration. Passed down through generations, this knowledge remains integral to many communities around the world.
Keithellakpam Ojit Singh, Khaidem Kennedy Singh, Ningombam Bishwamitra Singh, Nikki Konthoujam, Bhaskar Das, Tonjam Bidyasana Chanu, Biona Thokchom, Bunindro Nameirakpam, Shweta Rai, Neeta Pathaw, Oinam Shajan Singh, Bisheshwor Meitei Laishram, Pardeep Kumar Bhardwaj, Nanaocha Sharma   +13 more
doaj   +1 more source

BRICs Cooperação em comércio e indústria. Um ponto de vista do lado brasileiro / BRICS cooperation in trade and industry. A point of view from the brazilian side

Mural Internacional, 2010
O artigo examina a forme de inserção externa comercial do Brasil, traçando uma trajetória de sua evolução até a atualidade, quando o país se auto-define como global trader e global player.
José Botafogo Gonçalves
doaj   +1 more source

Traumatic brain injury in pedestrian–vehicle collisions: Convexity and suitability of some functionals used as injury metrics [PDF]

, 2016
Background and Objective: Abrupt accelerations or decelerations can cause large strain in brain tissues and, consequently, different forms of Traumatic Brain Injury (TBI). In order to predict the effect of the accelerations upon the soft tissues of the
Angelini, Massimo, Arregui Dalmases, Carlos, Crandall, Jeff R., Kerrigan, Jason, Sánchez Molina, David, Velázquez Ameijide, Juan   +5 more
core   +2 more sources