Results 41 to 50 of about 114,243 (331)

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

open access: yesFEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida   +6 more
wiley   +1 more source

Advancing Health through Physical Activity and Leisure in BRICS Plus Nations: A Report from the BRICSCESS Plus Association

open access: yesСпортивная медицина: наука и практика
The shift from BRICS to BRICS+ signifies a major step forward in global cooperation among emerging economies, with an emphasis on inclusivity, shared development, and collaboration among developing nations.
R. Ricci Uvinha   +2 more
doaj   +1 more source

Clostridioides difficile 630Δerm in silico and in vivo – quantitative growth and extensive polysaccharide secretion

open access: yesFEBS Open Bio, 2017
Antibiotic‐associated infections with Clostridioides difficile are a severe and often lethal risk for hospitalized patients, and can also affect populations without these classical risk factors.
Henning Dannheim   +3 more
doaj   +1 more source

Machine Learning for Green Solvents: Assessment, Selection and Substitution

open access: yesAdvanced Science, EarlyView.
Environmental regulations have intensified demand for green solvents, but discovery is limited by Solvent Selection Guides (SSGs) that quantify solvent sustainability. Training a machine learning model on GlaxoSmithKline SSG, a database of sustainability metrics for 10,189 solvents, GreenSolventDB is developed. Integrated with Hansen solubility metrics,
Rohan Datta   +4 more
wiley   +1 more source

Prospects of Legal Regulation of Extradition of Persons for Criminal Prosecution or Execution of a Sentence in the Context of the Expansion of BRICS

open access: yesBRICS Law Journal
This article presents the results of a systematic analysis of the legal regulation of extradition of persons for criminal prosecution or execution of a sentence in the BRICS (BRICS+) countries.
A. Volevodz, V. Karpovich
doaj   +1 more source

BRICS, SCO and new mechanisms of Global Governance

open access: yesМеждународная аналитика, 2015
The paper deals in detail with the purposes of creation and functioning of BRICS. The activities of BRICS and SCO are compared; the prospects of building new political, economic and financial architecture are examined.
G. Toloraya
doaj   +1 more source

Cybersecurity Policymaking in the BRICS Countries: From Addressing National Priorities to Seeking International Cooperation

open access: yesThe African Journal of Information and Communication, 2021
In the concluding statement of the 2021 BRICS Summit, the bloc’s five members—Brazil, Russia, India, China, and South Africa—pledged to pursue enhanced cooperation on cybersecurity issues, including by “establishing legal frameworks of cooperation among
Luca Belli
doaj   +1 more source

BRICS economic integration: Prospects and challenges

open access: yesSouth African Journal of International Affairs
Amid the evolving global economic landscape, the BRICS nations (Brazil, Russia, India, China, and South Africa) have emerged as proponents of economic multilateralism, challenging traditional paradigms of economic governance and integration. This article
Marida Nach, R. Ncwadi
semanticscholar   +1 more source

A Generalizable Transformer Framework for Gene Regulatory Network Inference from Single‐Cell Transcriptomes

open access: yesAdvanced Intelligent Systems, EarlyView.
FTGRN introduces an LLM‐enhanced framework for gene regulatory network inference through a two‐stage workflow. It combines a Transformer‐based model, pretrained on GPT‐4 derived gene embeddings and regulatory knowledge, with a fine‐tuning stage utilizing single‐cell RNA‐seq data.
Guangzheng Weng   +7 more
wiley   +1 more source

Scientific Diplomacy in BRICS+ Countries: From Strengthening Multilateralism to “Smart” Economy

open access: yesRUDN Journal of Economics
Scientific diplomacy is regarded as an effective tool for developing coordinated positions to overcome global challenges and reduce political tensions through the realization of three main purposes: “science in diplomacy”, “diplomacy for science”, and ...
Galina A. Khmeleva
doaj   +1 more source

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