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Cybersecurity Policymaking in the BRICS Countries: From Addressing National Priorities to Seeking International Cooperation

The African Journal of Information and Communication, 2021
In the concluding statement of the 2021 BRICS Summit, the bloc’s five members—Brazil, Russia, India, China, and South Africa—pledged to pursue enhanced cooperation on cybersecurity issues, including by “establishing legal frameworks of cooperation among
Luca Belli
doaj +1 more source

The rise of companies from emerging markets in global health governance: opportunities and challenges [PDF]

, 2014
The article analyses the involvement of pharmaceutical companies from emerging markets in global health governance. It finds that they play a central role as low-cost suppliers of medicines and vaccines and, increasingly, new technologies.
ANNE ROEMER-MAHLER +23 more
core +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida +6 more
wiley +1 more source

Machine Learning for Green Solvents: Assessment, Selection and Substitution

Advanced Science, EarlyView.
Environmental regulations have intensified demand for green solvents, but discovery is limited by Solvent Selection Guides (SSGs) that quantify solvent sustainability. Training a machine learning model on GlaxoSmithKline SSG, a database of sustainability metrics for 10,189 solvents, GreenSolventDB is developed. Integrated with Hansen solubility metrics,
Rohan Datta +4 more
wiley +1 more source

Mapping-based genome size estimation

BMC Genomics
While the size of chromosomes can be measured under a microscope, obtaining the exact size of a genome remains a challenge. Biochemical methods and k-mer distribution-based approaches allow only estimations. An alternative approach to estimate the genome
Shakunthala Natarajan, Jessica Gehrke, Boas Pucker +2 more
doaj +1 more source

Metabolic Reprogramming of Clostridioides difficile During the Stationary Phase With the Induction of Toxin Production

Frontiers in Microbiology, 2018
The obligate anaerobe, spore forming bacterium Clostridioides difficile (formerly Clostridium difficile) causes nosocomial and community acquired diarrhea often associated with antibiotic therapy.
Julia D. Hofmann +14 more
doaj +1 more source

Greening Capitalism? A Marxist Critique of Carbon Markets [PDF]

, 2012
Climate change is increasingly being recognized as a serious threat to dominant modes of social organization, inspiring suggestions that capitalism itself needs to be transformed if we are to ‘decarbonize’ the global economy. Since the Kyoto Protocol in
Abate R. S. +36 more
core +1 more source

A Generalizable Transformer Framework for Gene Regulatory Network Inference from Single‐Cell Transcriptomes

Advanced Intelligent Systems, EarlyView.
FTGRN introduces an LLM‐enhanced framework for gene regulatory network inference through a two‐stage workflow. It combines a Transformer‐based model, pretrained on GPT‐4 derived gene embeddings and regulatory knowledge, with a fine‐tuning stage utilizing single‐cell RNA‐seq data.
Guangzheng Weng +7 more
wiley +1 more source

Just another BRIC in the wall? The rise of BRICs and educating tomorrow's global managers [PDF]

, 2012
The BRIC countries (Brazil, Russia, India, and China) comprise 40 percent of the world’s population (approximately 2.8 billion people), cover more than a quarter of the world’s land area over three continents, and account for more than 25 percent of ...
Salmi, Asta, Scott-Kennel, Joanna
core +1 more source

Are There Causal Associations Between Obsessive‐Compulsive Disorder and Cardiometabolic Phenotypes? A Genetic Correlation and Bi‐Directional Mendelian Randomization Study

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT In epidemiological studies, obsessive‐compulsive disorder (OCD) is robustly associated with increased risk of cardiometabolic disorders, including cardiovascular diseases, type 2 diabetes, and obesity. However, the mechanisms behind these associations are unclear. We conducted genetic correlation analyses to explore shared genetic etiology and
Robyn E. Wootton +217 more
wiley +1 more source

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