Results 31 to 40 of about 1,020,994 (316)

Development of Antibody Arrays for Monoclonal Antibody Higher Order Structure Analysis

Frontiers in Pharmacology, 2013
Antibody arrays were developed to probe a monoclonal antibody’s three-dimensional structure (3-D structure). Peptides with overlapping regions were designed to cover the whole mAb light chain and heavy chain respectively and used to generate polyclonal ...
Xing eWang, Qing eLi, Michael eDavies
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Bridging consent: from toll bridges to lift bridges? [PDF]

BMC Medical Genomics, 2011
The ability to share human biological samples, associated data and results across disease-specific and population-based human research biobanks is becoming increasingly important for research into disease development and translation. Although informed consent often does not anticipate such cross-domain sharing, it is important to examine its ...
Isabelle Budin-Ljøsne, Anne Tassé, Bartha Knoppers, Jennifer R Harris   +3 more
openaire   +3 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

The Effect of Lane Changing on Long-Span Highway Bridge Traffic Loading

, 2012
Bridge Maintenance, Safety, Management, Resilience & Sustainability, Sixth International IABMAS Conference, Stresa, Lake Maggiore, Italy, 8-12 July 2012Maximum loading on long-span bridges typically occurs in congested traffic conditions.
Carey, Colm, B Enright, E OBrien, O\u27Brien, Eugene J., C Carey, O'Brien, Eugene J., Enright, Bernard, C Caprani, Caprani, Colin C.   +8 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Justification of the development and application of express assessment programs for road bridges when heavy vehicles pass through them

Structural Mechanics of Engineering Constructions and Buildings, 2021
The theoretical prerequisites for justifying the development of two rapid assessment programs for road bridges to quickly determine the possibility of passing heavy vehicles on road bridge structures of a split and non-split system, made of wood, metal ...
Evgeny A. Lugovtsev
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

(Per)forming identity in the mind-sport bridge: Self, partnership and community [PDF]

, 2021
Mind-sports are a relatively under-explored area within the sociology of sport, especially the internationally played game of bridge. In this qualitative sociological study of tournament bridge, we examine the formation and performance of elite bridge ...
Cairns, Beth, Cairns , Beth, Russell, Zoe; id_orcid, Russell, Zoe, Punch, Samantha   +4 more
core   +1 more source