Results 51 to 60 of about 1,020,994 (316)

Seismic Performance Assessment of Deteriorated Two-Span Reinforced Concrete Bridges

open access: yesInternational Journal of Concrete Structures and Materials, 2022
This paper presents a nonlinear analysis procedure for the seismic performance assessment of deteriorated reinforced concrete bridges using a modified damage index.
Tae-Hoon Kim
doaj   +1 more source

Bridge roughness index as an indicator of bridge dynamic amplification

open access: yes, 2006
The concept of a road roughness index for bridge dynamics is developed. The International Roughness Index (IRI) is shown to be very poorly correlated with bridge dynamic amplification as it takes no account of the location of individual road surface ...
O'Brien, Eugene J.   +2 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Shape Stabilization of Steel Suspension Bridge

open access: yesThe Baltic Journal of Road and Bridge Engineering, 2008
Stabilization of primary shape of suspension bridge is one of the governing design problems of the structure. The form, i.e. shape changes of suspension steel bridge, is prescribed more by kinematic vs elastic displacements.
Algirdas Juozapaitis   +2 more
doaj   +1 more source

Bridge, Reverse Bridge, and Their Control

open access: yesEntropy
We investigate the bridge problem for stochastic processes, that is, we analyze the statistical properties of trajectories constrained to begin and terminate at a fixed position within a time interval τ. Our primary focus is the time-reversal symmetry of these trajectories: under which conditions do the statistical properties remain invariant under the
Baldassarri, Andrea, Puglisi, Andrea
openaire   +3 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Estimation of Extreme Load Effects on Long-Span Bridges Using Traffic Image Data

open access: yesThe Baltic Journal of Road and Bridge Engineering, 2018
This paper proposes an algorithm for the estimation of extreme intensity of traffic load on long-span bridges. Most Weigh-in-Motion technologies do not operate in congested conditions which are the governing cases for these bridges.
Elena Alexandra Micu   +3 more
doaj   +1 more source

Immediate Versus Delayed Loading of Implant for Replacement of Missing Mandibular First Molar: A Randomized Prospective Six Years Clinical Study [PDF]

open access: yesJournal of Clinical and Diagnostic Research, 2017
Introduction: Emergence of dental implants made the replacement of missing tooth easy. During the early days of introduction, implants were loaded three to six months after implant insertion, but understanding of healing cascade and improved ...
Prudhvi Raj Lakshmi Venkata Chidagam   +5 more
doaj   +1 more source

Wind loads analysis at the anchorages of the Talavera de la Reina cable stayed bridge [PDF]

open access: yes, 2014
This paper describes wind tunnel tests performed on wind tunnel models of the Talavera de la Reina cable stayed bridge. The work describes the aeroelastic model construction and it is focused on the evaluation and analysis of the mean and peak wind loads
Squicciarini, G.   +9 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

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