Results 81 to 90 of about 3,475,758 (325)

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Prevalence of Respiratory Syncytial Virus in Adult Patients with Respiratory Illnesses in Low to Middle-Income Countries: A Systematic Review and Meta-Analyses

Infectious Diseases and Therapy
Introduction There is a gap in the understanding of the burden of respiratory syncytial virus (RSV) among adults in low, lower-middle, and upper-middle income countries, particularly with regard to up-to-date epidemiological data.
Digant Gupta, Amandeep Kaur, Vikas Verma, Désirée A. M. Van Oorschot, Yolanda Penders, Adriana Guzman-Holst   +5 more
doaj   +1 more source

Non-minimal bridge positions of torus knots are stabilized

, 2010
We show that any non-minimal bridge decomposition of a torus knot is stabilized and that $n$-bridge decompositions of a torus knot are unique for any integer $n$. This implies that a knot in a bridge position is a torus knot if and only if there exists a
Bonahon, Hayashi, Kobayashi, MAKOTO OZAWA, Markov, Otal, Otal, Scharlemann   +7 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Mapping the evaluation of the electronic health system PEC e-SUS APS in Brazil: a scoping review protocol

Systematic Reviews
Background The Brazilian Ministry of Health has developed and provided the Citizen’s Electronic Health Record (PEC e-SUS APS), a health information system freely available for utilization by all municipalities.
Mariano Felisberto, Júlia Meller Dias de Oliveira, Eduarda Talita Bramorski Mohr, Daniel Henrique Scandolara, Ianka Cristina Celuppi, Miliane dos Santos Fantonelli, Raul Sidnei Wazlawick, Eduardo Monguilhott Dalmarco   +7 more
doaj   +1 more source

Evaluation of High-Speed Railway Bridges Based on a Nondestructive Monitoring System

Applied Sciences, 2016
Recently, trains’ velocities in Korea increased more than the speed used in the design of some bridges. Accordingly, this paper demonstrates the evaluation of a railway bridge due to high-speed trains’ movement. A nondestructive monitoring system is used
Mosbeh R. Kaloop, Jong Wan Hu, Emad Elbeltagi   +2 more
doaj   +1 more source

Design and implementation of a HLA inter-federation bridge [PDF]

, 2003
In this paper, we discuss the design and implementation of a HLA inter-federation bridge. Our works are mainly motivated by the scalability and security problems, but we also consider the use of bridges for interoperability purposes.
Bréholée, Benoît, Siron, Pierre
core  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Bridging Bridges [PDF]

Proceedings of the Manchester Pharmacy Education Conference, 2014
Julie Letchford, Keith Brown
openaire   +2 more sources