Advanced Science, EarlyView.CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu +13 more
wiley +1 more source
Transparency of Monetary Policy: Theory and Practice [PDF]
Transparency has become one of the main features of monetary policymaking during the last decade. This paper establishes some stylized facts. In addition, it provides a systematic overview of the practice of monetary policy transparency around the world.
Petra Geraats
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Central Bank’s Role and Involvement in Bank Regulation: Lender of Last Resort Arrangements and the Special Resolution Regime (SRR) [PDF]
, 2011 This paper considers developments which have necessitated greater involvement and a greater role for the central bank in financial regulation and supervision. The aftermath of the 2007/08 Financial Crisis has witnessed the enactment of legislation such
Ojo, Mariane.B.
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Integrated Solutions Development Capital Solutions Interim Report Volume I: Report [PDF]
, 1998 This report analyzes the water quality, flood, erosion, and integrated scores of multiple Austin watersheds, including Waller Creek.Waller Creek Working ...
Loomis & More, Inc. +1 more
core +1 more source
Molecular Glue cc‐885 Inhibits VHL‐Deficient Clear Cell Renal Cell Carcinoma via ETS1 Degradation
Advanced Science, EarlyView.VHL‐deficient kidney cancer lacks effective treatments. This study reveals that the molecular glue degrader cc‐885 hijacks the cellular recycling system to selectively destroy the oncogenic protein ETS1, effectively killing VHL‐mutant tumors. Combining CC‐885 with the approved drug belzutifan achieves powerful synergy, offering a promising new ...
Taowei Yang +15 more
wiley +1 more source
The Bank of Finland Foreign Trade Survey 1995–1996: A Quality Evaluation [PDF]
In order to bridge temporary delays in the dissemination of official foreign trade statistics compiled by the National Board of Customs after the Finland's entry into the EU in 1995, the Bank of Finland decided to introduce a special survey on Finnish ...
Hakuni, Mika, Hilpinen, Jorma
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Learning journeys: sharing resources for embedding progressive learning development [PDF]
, 2014 Following on from work done on integrating learning development into the curriculum (Hill and Tinker, 2013), we have since concentrated on specific aspects of student progression, and in particular how the ‘forgotten’ second year of study (Tobolowsky ...
Hill, Pat, Tinker, Amanda
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Ammonia Detoxification Inhibits Liver Metastasis by Reshaping Hepatic Microenvironment
Advanced Science, EarlyView.Liver metastasis diverts aspartate into hyperactive pyrimidine synthesis, disrupting urea cycling and causing pathogenic ammonia accumulation. Ammonia dually reprograms the microenvironment by: (1) activating hepatic stellate cells (HSCs) into pro‐fibrotic metastasis‐associated fibroblasts (MAFs), and (2) suppressing anti‐tumor monocytes/macrophages ...
Sumin Sun +5 more
wiley +1 more source
Two – Dimensional Mathematical Model to Study Erosion Problem of Tigris River Banks at Nu’maniyah
Journal of Engineering, 2017 The high and low water levels in Tigris River threaten the banks of the river. The study area is located on the main stream of Tigris River at Nu’maniyah City and the length of the considered reach is 5.4 km, especially the region from 400 m upstream Nu ...
Hayder AbdulAmeer. K. AL-Thamiry, Ass. Prof. Dr. +1 more
doaj
Quantification of channel planform change on the lower Rangitikei River, New Zealand, 1949-2007: response to management? [PDF]
, 2010 The Rangitikei River, a large gravel‐bed wandering river located in the North Island of New Zealand, has outstanding scenic characteristics, recreational, fisheries and wildlife habitat features.
Fuller, Ian C, Richardson, Jane M.
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