Results 171 to 180 of about 1,215,022 (288)

Viridicatol from the Deep‐Sea‐Derived Fungus Alleviates Bone Loss by Targeting the Wnt/SHN3 Pathway

open access: yesAdvanced Science, EarlyView.
Viridicatol (VDC), isolated from the deep‐sea‐derived fungus, enhances osteogenesis in vitro and in vivo by targeting Wnt/SHN3 signaling pathway. It can be delivered via engineered nanovesicles to mitigate bone loss of osteoporosis, fracture repair, and osteogenesis imperfecta.
Chun‐Lan Xie   +10 more
wiley   +1 more source

Inhibition of Ferroptosis Delays Aging and Extends Healthspan Across Multiple Species

open access: yesAdvanced Science, EarlyView.
This study identifies ferroptosis as a key driver of cellular senescence, with its inhibition delaying aging and extending healthspan across species. During senescence, ferroptosis worsens, increasing oxidative stress and lipid peroxidation, which accelerate aging.
Hai‐Jun Fu   +15 more
wiley   +1 more source

DiffMC‐Gen: A Dual Denoising Diffusion Model for Multi‐Conditional Molecular Generation

open access: yesAdvanced Science, EarlyView.
DiffMC‐Gen, a dual‐diffusion model for 2D and 3D molecular generation, simultaneously optimizes multiple key objectives across the drug design process, enabling the generation of novel, target‐specific small‐molecule ligands with high therapeutic potential.
Yuwei Yang   +7 more
wiley   +1 more source

Elastic Deformation of Cellulose/Lignin‐Based Anode for Rejuvenating Aged Mix‐Cultured Electroactive Biofilms

open access: yesAdvanced Science, EarlyView.
A new strategy for revitalizing aged biofilms using the elastic deformation of biomass‐based flexible carbon aerogel is proposed. The elastic deformation removes the nonelectrogenic bacteria and the dead electrogenic bacteria, as well as a lot of loosely bound extracellular polymer materials.
Xue Liu   +15 more
wiley   +1 more source

Recent Advances in Xenes Based FET for Biosensing Applications

open access: yesAdvanced Science, EarlyView.
Xenes (monoelemental 2D materials like graphene, phosphorene, tellurene) enable ultrasensitive FET (Field‐Effect Transistor) biosensors due to their tunable bandgap, high carrier mobility, and large surface area. Advances in synthesis (CVD, MBE) and functionalization allow detection of DNA/RNA (via CRISPR‐Cas systems), proteins, small molecules, and ...
Huide Wang   +9 more
wiley   +1 more source

Ship-Bridge Collision Real-Time Alarming Method Based on Cointegration Theory. [PDF]

open access: yesSensors (Basel)
Zhong W   +6 more
europepmc   +1 more source

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