Viridicatol from the Deep‐Sea‐Derived Fungus Alleviates Bone Loss by Targeting the Wnt/SHN3 Pathway
Viridicatol (VDC), isolated from the deep‐sea‐derived fungus, enhances osteogenesis in vitro and in vivo by targeting Wnt/SHN3 signaling pathway. It can be delivered via engineered nanovesicles to mitigate bone loss of osteoporosis, fracture repair, and osteogenesis imperfecta.
Chun‐Lan Xie+10 more
wiley +1 more source
Graph theory approaches for molecular dynamics simulations. [PDF]
Patel AC, Sinha S, Palermo G.
europepmc +1 more source
Inhibition of Ferroptosis Delays Aging and Extends Healthspan Across Multiple Species
This study identifies ferroptosis as a key driver of cellular senescence, with its inhibition delaying aging and extending healthspan across species. During senescence, ferroptosis worsens, increasing oxidative stress and lipid peroxidation, which accelerate aging.
Hai‐Jun Fu+15 more
wiley +1 more source
Enhancing security in electromagnetic radiation therapy using fuzzy graph theory. [PDF]
Lal R, Singh RK, Nishad DK, Khalid S.
europepmc +1 more source
DiffMC‐Gen: A Dual Denoising Diffusion Model for Multi‐Conditional Molecular Generation
DiffMC‐Gen, a dual‐diffusion model for 2D and 3D molecular generation, simultaneously optimizes multiple key objectives across the drug design process, enabling the generation of novel, target‐specific small‐molecule ligands with high therapeutic potential.
Yuwei Yang+7 more
wiley +1 more source
Enhanced thermal conductivity of Cu Grafted graphene-C<sub>2</sub>H<sub>6</sub>O<sub>2</sub> based nanofluids by laser ablation for potential application as coolants in data centers. [PDF]
Aligholami M+7 more
europepmc +1 more source
A new strategy for revitalizing aged biofilms using the elastic deformation of biomass‐based flexible carbon aerogel is proposed. The elastic deformation removes the nonelectrogenic bacteria and the dead electrogenic bacteria, as well as a lot of loosely bound extracellular polymer materials.
Xue Liu+15 more
wiley +1 more source
Symptomatic Pathways of Comorbid Depression, Anxiety, and Stress Among Adolescents Exposed to Childhood Trauma-Insights from the Network Approach. [PDF]
Zou X+6 more
europepmc +1 more source
Recent Advances in Xenes Based FET for Biosensing Applications
Xenes (monoelemental 2D materials like graphene, phosphorene, tellurene) enable ultrasensitive FET (Field‐Effect Transistor) biosensors due to their tunable bandgap, high carrier mobility, and large surface area. Advances in synthesis (CVD, MBE) and functionalization allow detection of DNA/RNA (via CRISPR‐Cas systems), proteins, small molecules, and ...
Huide Wang+9 more
wiley +1 more source
Ship-Bridge Collision Real-Time Alarming Method Based on Cointegration Theory. [PDF]
Zhong W+6 more
europepmc +1 more source