Highly functionalised fused heterocycle synthesis from fluoropyridines [PDF]
, 2006 Current approaches to drug discovery tends to involve the rapid analogue synthesis and testing of small, focused libraries of low molecular weight, structurally similar "drug-like" molecules, often based around heterocyclic core scaffolds.
Cartwright, Matthew William
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A study of the thermally-induced cyclisations of some polyfluoroaromatic hydrazones leading to Fischer indole products [PDF]
, 1983 Previously acetophenone 1,3,4,5,6,7,8-heptafluoro-2-naphthylhydrazone and acetophenone pentafluorophenylhydrazone were reported to react in tetralin at reflux temperature to give among the products 4,5,6,7,8,9- hexafluoro-2-phenylbenz[ e ]indole and 4,5 ...
Benke, Frank Dominic
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A Small Molecule Scaffold Analysis: Biological Profiles of Novel, Privileged, and Promiscuous Scaffolds [PDF]
, 2013 Owing to the better understanding of physiochemical and biological challenges associated with the bioactivity of small organic molecules, novel scaffolds are becoming more extensively engineered and more highly optimized.
Hammad, Layal
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The synthesis and properties of some well-defined fluorinated polymers [PDF]
, 1996 This thesis describes studies directed to the ring opening metathesis polymerisation (ROMP) of some fluorinated compounds using a range of well-defined initiators.
Towns, Richard Mark
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Rhodium(I)-Catalyzed Annulation of Bicyclo[1.1.0]butyl-Substituted Dihydroquinolines and Dihydropyridines [PDF]
Bicyclo[1.1.0]butane-containing compounds feature a unique chemical reactivity, trigger “strain-release” reaction cascades, and provide novel scaffolds with considerable utility in the drug discovery field.
Wipf, Peter +5 more
core +1 more source
Synthesis and Pharmacological Properties of Heterocyclic Analogs [PDF]
, 2009 Not ...
Pansuriya, Akshay M.
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, 2003 Previous pharmacological results have suggested that members of the heterocyclic bicyclo[3.3.1]nonan- 9-one-like compounds are potent κ-opioid receptor specific agonists.
Borsodi, Anna +4 more
core +1 more source
B(C6F5)3-Catalyzed Formal (n+3) (n = 5,6) Cycloaddition of Bicyclo[1.1.0]butanes to Medium Bicyclo[n.1.1]alkanes [PDF]
Herein, a B(C6F5)3-catalyzed formal (n+3) (n = 5,6) cycloaddition of bicyclo[1.1.0]butanes (BCBs) with imidazolidines/hexahydropyrimidines is described.
Ming, Lang +4 more
core +2 more sources
Diffraction and database analyses of photoactive biphenyl compounds and novel carbaborane structures [PDF]
, 1999 The research involved in this thesis is mainly concerned with crystallography and the analysis using crystallographic techniques and methods. The work in this thesis is centered mainly on two types of chemical compounds, photoactive compounds and ...
Mackinnon, Angus
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