Results 21 to 30 of about 2,106,514 (153)

A Review on Five and Six-Membered Heterocyclic Compounds Targeting the Penicillin-Binding Protein 2 (PBP2A) of Methicillin-Resistant Staphylococcus aureus (MRSA)

Molecules, 2023
Staphylococcus aureus is a common human pathogen. Methicillin-resistant Staphylococcus aureus (MRSA) infections pose significant and challenging therapeutic difficulties.
S. S. Ambade, V. K. Gupta, R. Bhole, P. Khedekar, R. Chikhale   +4 more
semanticscholar   +1 more source

1‐Azabicyclo[1.1.0]butanes (ABBs) on the Map: Mechanistic Pathways for Catalytic Ring Opening and Functionalizations

Angewandte Chemie, Volume 138, Issue 46, 9 November 2026.
Catalytic strain‐release ring opening and functionalizations of 1‐azabicyclo[1.1.0]butanes (ABBs) represent a promising strategy for accessing diverse azetidine products. These transformations proceed via polar pathways, radical pathways, and hybrid mechanisms that combine both.
James Shao‐Jiun Yang, Hsuan‐Hung Liao   +1 more
wiley   +2 more sources

NHC‐Copper(I)‐Mediated Functionalization of White Phosphorus

Angewandte Chemie, Volume 138, Issue 45, 2 November 2026.
White phosphorus is functionalized by N‐heterocyclic carbene supported copper(I) complexes through redox‐neutral steps. Treatment of the resulting complexes with electrophiles releases the ligands from the metal center as asymmetrically substituted organophosphorus butterfly compounds.
Thomas M. Horsley Downie, Sophia A. Vogler, Gábor Balázs, Francesco Cirigliano, Robert Wolf   +4 more
wiley   +2 more sources

Synthesis and Reactivity of Triphosphaallyl Cation Stabilized by N‐Heterocyclic Carbenes

Chemistry
Reduction of the triphosphaallyl species 6[GaCl4] with GaI[Ga2Cl7] affords the imidazoliumyl‐substituted (L) bicyclo[2.1.1]‐triphosphane 10[Ga2Cl7], featuring an unprecedented Ga2Cl5‐bridged P3 scaffold.
Julia Frötschel-Rittmeyer, Felix Hennersdorf, Jannis Fidelius, Chris H. Sala, Christoph G. P. Ziegler, Michael H. Holthausen, K. Schwedtmann, Robert Wolf, Jan J. Weigand   +8 more
semanticscholar   +1 more source

Organocatalytic Synthesis of Spiro-Bridged Heterocyclic Compounds via a Chemoselective Vinylogous Michael/Cyclization/Rearrangement Sequence

Journal of Organic Chemistry
An organocatalytic cascade reaction of 2-ethylidene 1,3-indandiones and isatylidene-malononitriles has been achieved using quinine as the catalyst. The unexpected vinylogous Michael addition at the β position of isatylidene-malononitriles, followed by ...
I-Ting Chen, Hsuan-Yu J. Lin, Jeng-Liang Han   +2 more
semanticscholar   +1 more source

Remapping the Synthetic Landscape of α‐Tertiary Alkylamines via Dual‐Functional Catechol

Angewandte Chemie, Volume 138, Issue 37, 7 September 2026.
A three‐component assembly strategy has been developed for the modular synthesis of hindered α‐tertiary aliphatic amines from readily available precursors through unlocking the dual role of catechol. The practicality of this methodology has been demonstrated in over 90 examples, including compounds that are otherwise difficult to access, along with ...
Chen‐Yan Cai, Yuzuru Kanda, Tian Qin
wiley   +2 more sources

Bicyclo[2.1.1]hexanes by Visible Light-Driven Intramolecular Crossed [2 + 2] Photocycloadditions

, 2022
Bicyclo[2.2.1]hexanes have become increasingly popular building blocks in medicinal chemistry as bridged scaffolds that provide unexplored chemical space.
Thorsten Bach (1397326), Thomas Rigotti (5333960)   +1 more
core   +2 more sources

Activation of Metal Complexes With Ultrasound Waves for Targeted Anticancer Therapy

Angewandte Chemie International Edition, EarlyView.
Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean, Nicolás Montesdeoca, Gilles Berger, Johannes Karges   +3 more
wiley   +1 more source

Enantioselective Synthesis of Bridged Bicyclic Ring Systems

, 2016
The type 2 intramolecular Diels−Alder (IMDA) reaction is a valuable method for synthesis of both carbocyclic and heterocyclic bridged bicyclo[5.3.1]undecane and bicyclo[4.3.1]decane ring systems.
Liang Zhu (172992), Kenneth J. Shea (1306059), John A. Brailsford (1332951), Mandy Loo (2466646)   +3 more
core   +1 more source

Trends and Future Directions in Organic Chemistry for Drug Discovery

Chemistry – A European Journal, EarlyView.
Organic synthesis is being reshaped by the convergence of catalytic innovation, automation, artificial intelligence, and emerging therapeutic modalities. Late‐stage functionalization, photoredox and electrochemical methods, biocatalysis, flow chemistry, DELs, and proximity‐based drugs are examined as components of closed‐loop discovery.
Paweł Kozyra, Maciej Masłyk
wiley   +1 more source