Rhodium(I)-Catalyzed Annulation of Bicyclo[1.1.0]butyl-Substituted Dihydroquinolines and Dihydropyridines [PDF]
Journal of the American Chemical SocietyBicyclo[1.1.0]butane-containing compounds feature a unique chemical reactivity, trigger “strain-release” reaction cascades, and provide novel scaffolds with considerable utility in the drug discovery field.
Matteo Borgini +5 more
semanticscholar +2 more sources
Switchable organocatalytic enantioselective sulfenocyclization of cyclohexadienes enabling chemodivergent access to chiral bicyclo[m.n.1] ring systems. [PDF]
Nat CommunThe precise control over regio- and stereoselectivity from the same substrate represents a significant challenge in organic chemistry. Herein, a switchable organocatalytic enantioselective carbosulfenylation/sulfenolactonization of cyclohexa-1,4-dienes ...
Zhang BQ +5 more
europepmc +2 more sources
Enantioselective Synthesis of 2-Oxabicyclo[2.1.1]hexanes and Bicyclo[2.1.1]hexanes via Catalytic Asymmetric Intramolecular Photocycloadditions. [PDF]
Nat CommunDue to the ubiquitous presence of ortho-disubstituted benzenes in pharmaceuticals and agrochemicals, the exploration of their bioisosteres incorporating three-dimensional bridged cyclic scaffolds has attracted significant interest among chemists in ...
Tian D +6 more
europepmc +2 more sources
Studies of novel nitro-substituted nitrogen heterocyclic compounds [PDF]
, 2001 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The novel candidate high energy insensitive explosive; 2,5-diamino-3,6-dinitropyrazine (ANPZ-i) has been prepared in acceptable overall yield.
Philbin, Simon Patrick
core +8 more sources
A de-novo Approach Towards Divergent [3+2π/σ] Photocycloadditions of Nitrones via Assembly-Controlled Kinetic Electron Transfer Gating. [PDF]
Angew Chem Int Ed EnglA metal‐free photocatalytic platform converts nitrones into 4‐isoxazolines and oxa–aza–bicycloheptanes through divergent [3+2π/σ] cycloadditions. Assembly‐controlled kinetic electron transfer gating dictates substrate activation, enabling selective reactivity beyond thermodynamic expectations.
Saha N +6 more
europepmc +3 more sources
Bridged Bicyclic Compounds [PDF]
, 1973 This thesis is concerned with certain aspects of the application of Bredt's Rule in bridged bicyclic compounds. The reported monodecarboxylation of bicyclo[2,2,2]-octane-2,5-dione-1,4-dicarboxylic acid (1) to give bicyclo-[2,2,2]octane-2,5-dione-l ...
Kean, Norman Buchanan
core +4 more sources
Biointerface Research in Applied Chemistry, 2022 In this paper, a theoretical study has been carried out. This study concerns four organic dyes with structure D–π–A on the base of triphenylamine; we choose thiophene and thieno [3, 4-b] pyrazine group as a donor and the group cyanoacrylic acid as an ...
M. Raftani +6 more
semanticscholar +1 more source
Bicyclo[m.n.k]alkane Building Blocks as Promising Benzene and Cycloalkane Isosteres: Multigram Synthesis, Physicochemical and Structural Characterization [PDF]
, 2023 Electrophilic double bond functionalization – intramolecular enolate alkylation sequence was used to obtain a series of bridged and fused bicyclo[m.n.k]alkane derivatives (i.e., bicyclo[4.1.1]octanes, bicyclo[2.2.1]heptanes, bicyclo[3.2.1]octanes ...
Ihor, Fesun +9 more
core +1 more source
Pharmaceuticals, 2021 Antimitotic drugs that target tubulin are among the most widely used chemotherapeutic agents; however, the development of multidrug resistance has limited their clinical activity.
A. Malebari +10 more
semanticscholar +1 more source
1,1’‐Ferrocenylene‐Bridged Bis(N‐Heterocyclic Olefin) Derivatives
European Journal of Inorganic Chemistry, 2021 The 1,1 ’ -ferrocenylene (fc)-bridged bis(N-heterocyclic olefin) compounds (IMes = CH) 2 fc ( 1 , IMes = 1,3-dimesitylimidazolin-2-ylidene) and (IPr = CH) 2 fc ( 2 , IPr = 1,3-bis(2,6-diisopropylphenyl)imidazolin-2-ylidene) were synthesised from (ICH 2 )
Robin Guthardt +3 more
semanticscholar +1 more source